What is Zestoretic: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 31, 2020

Zestoretic overview

BRAND NAMES:

  • Prinzide, Zestoretic

Generic Names:

  • Lisinopril-Hydrochlorothiazide

Uses:

  • Treats high blood pressure. This medicine contains an ACE inhibitor and a diuretic (water pill).

Therapeutic Classes:

  • ACE Inhibitor/Thiazide Combination, Antihypertensive, Cardiovascular Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What form(s) does Zestoretic come in

  • Tablet

What are common Zestoretic doses?

  • Tablet 20-12.5MG

  • Tablet 20-25MG

  • Tablet 10-12.5MG

Common Zestoretic prescriptions

  • Zestoretic
    100 tablets bottle

  • Zestoretic
    10-12.5mg tablet

  • Zestoretic
    20-12.5mg tablet

  • Zestoretic
    20-25mg tablet

How to take Zestoretic

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Swallow the tablet whole. Do not break, crush, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the tablet whole. Do not break, crush, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Zestoretic contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to lisinopril, hydrochlorothiazide, another ACE inhibitor, or a sulfa drug, or if you are pregnant or cannot pass urine, or if you have a history of angioedema caused by an ACE inhibitor.

Zestoretic warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine is not safe to take during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart failure, diabetes, high cholesterol, gout, lupus, trouble urinating, or a history of allergies or asthma, or if you have had surgery of the nerves.

  • This medicine may cause the following problems:Angioedema (severe swelling), including head, neck, and intestinal swellingLow blood pressureLiver problemsEye or vision problems, including glaucoma, myopiaKidney problemsHigh uric acidHigh cholesterol or fats in the bloodIncreased risk for skin cancer

  • This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.

  • Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.

  • Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Zestoretic interactions

  • Do not use this medicine together with aliskiren if you have diabetes.

  • Do not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan within 36 hours of each other.

  • Some foods and medicines can affect how lisinopril/hydrochlorothiazide works. Tell your doctor if you are using any of the following:Aliskiren, cholestyramine, colestipol, everolimus, gold injection, lithium, sirolimus, temsirolimusAnother blood pressure medicine, including an angiotensin receptor blocker (ARB)Insulin or oral diabetes medicineNSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, or naproxen)Steroid medicine (including hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used together with this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zestoretic side effects

Serious Side Effects

  • Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin

  • Blistering, peeling, red skin rash

  • Fever, chills, sore throat, body aches

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Lightheadedness, dizziness, fainting

  • Dry mouth, increased thirst, muscle cramps

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate

  • Severe stomach pain

  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips

  • Eye pain, vision changes, seeing halos around lights

Less Serious Side Effects

  • Dry cough