Eliquis
Apixaban
Treats and prevents blood clots.
Oral anticoagulant, factor Xa inhibitor
Tablet
By mouth
Eliquis is an oral anticoagulant that prevents or treats blood clots. It helps prevent blood clots after a hip or knee replacement or in people with atrial fibrillation or who have just been treated for a blood clot in the lungs (pulmonary embolism or PE) or in a leg (deep vein thrombosis or DVT). It also treats existing blood clots in people with pulmonary embolism or deep vein thrombosis.
Tablet
2.5 mg
5 mg
To prevent blood clots in the legs in adults after hip or knee replacement: 2.5 mg taken by mouth twice per day for 35 days (hip replacement) or 12 days (knee replacement
To prevent stroke or blood clots in adults with atrial fibrillation: 5 mg taken by mouth twice per day
To treat DVT or PE in adults: 10 mg taken by mouth twice daily for 7 days followed by 5 mg taken by mouth twice daily
To prevent recurrence of DVT or PE in adults: 2.5 mg taken by mouth twice per day for at least 6 months
RELATED: Eliquis dosage, forms, and strengths
Eliquis
60 tablets bottle
Eliquis
2.5mg tablet
Eliquis
5mg tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Take Eliquis tablets twice per day.
Eliquis can be taken with or without food.
If you are not able to swallow the tablets whole, ask the prescriber for directions on crushing the tablets.
Eliquis tablets may be crushed and mixed in water, apple juice, or applesauce.
Take the mixture immediately.
For use with a nasogastric feeding tube (NGT), ask the prescriber for directions.
Eliquis tablets can be crushed and mixed with 60 mL of water for administration through a nasogastric tube (NGT).
It’s hazardous to miss Eliquis doses. Refill the prescription before you run out of pills.
Store Eliquis in a closed container at room temperature.
Do not skip Eliquis doses.
Ask the doctor for specific directions about what to do if a dose is missed.
According to the manufacturer, missed doses should be taken as soon as they’re remembered on the same day.
Do not take two doses at the same time.
After taking the missed dose, resume the twice-daily dosing.
This medicine is not right for everyone.
Do not use it if you have had an allergic reaction to apixaban or you have active abnormal bleeding.
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
Your doctor will do lab tests regularly to check on the effects of this medicine. Keep all appointments.
Tell any doctor or dentist who treats you that you are using this medicine. With your doctor's supervision, you may need to stop using this medicine several days before you have surgery or medical tests.
Do not stop using this medicine suddenly without asking your doctor. You might have a higher risk of stroke or blood clots for a short time after you stop using this medicine.
Eliquis can cause serious problems:
This medicine increases your risk for bleeding that can become serious or life-threatening if not controlled. Familiarize yourself with the signs and symptoms of blood loss and tell a doctor immediately or go to an emergency room if they occur.
You may also bruise easily, and it may take longer than usual for bleeding to stop.
This medicine may increase your risk for a hematoma (blood clot) in your spine or back if you undergo an epidural or spinal puncture. This could lead to paralysis. Tell your doctor if you ever had spine problems or back surgery.
Tell your doctor if you are pregnant or breastfeeding.
Tell your doctor if you have:
Kidney disease
Liver disease
A history of bleeding problems
Antiphospholipid syndrome, an autoimmune disease that can cause blood clots
An artificial heart valve
Any other medical conditions
Keep this medicine out of the reach of children. Never share Eliquis with anyone.
To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, vitamins, and supplements you use before taking Eliquis.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Some medicines may increase the risk of bleeding or stroke when combined with Eliquis. Tell your doctor if you are also taking:
Blood thinners
NSAIDs such as ibuprofen
Aspirin or aspirin-containing products
The anticonvulsants carbamazepine or phenytoin
The antifungal drugs ketoconazole or itraconazole
The tuberculosis drug rifampin
The antiviral drug ritonavir
The herbal supplement St. John’s wort
Find more detailed information about Eliquis interactions to avoid here.
Serious side effects
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect including:
Signs of bleeding problems or blood loss:
Unexpected bleeding, unusual bleeding, severe bleeding, frequent nosebleeds, or frequent bruising
Red, pink, or brown urine
Red or black, tarry stools
Coughing up blood or blood clots
Vomiting blood or blood clots (“coffee-ground vomit”)
Headaches, dizziness, weakness
Sudden pain, swelling, or joint pain
Numbness, tingling, or muscle weakness in your legs or feet following an epidural or spinal puncture
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, wheezing, sudden chest pain or chest tightness
Less serious side effects
Nosebleed
Bruising easily
Protracted bleeding from small injuries
Nausea
Find more detailed information about Eliquis side effects here.
Eliquis apixaban tablet prescribing information, NIH National Library of Medicine
Eliquis consumer website, Bristol Myers Squibb
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