What is Euthyrox: Uses, Warnings & Interactions

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist
Updated Apr 2, 2024  •  Published Dec 30, 2020
Fact Checked

Euthyrox overview

BRAND NAMES:

  • Euthyrox

Generic Names:

  • Levothyroxine sodium

Uses:

  • Treats hypothyroidism (the body does not produce enough thyroid hormone)

  • Reduces the size of an enlarged thyroid gland

  • Treats some thyroid cancers in addition to surgery and radioiodine therapy

Therapeutic Classes:

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Euthyrox used for?

Euthyrox is a synthetic T4 hormone that is used to treat an underactive thyroid gland. Euthyrox is one of levothyroxine sodium’s available brand names, but it has only been proven to be bioequivalent to Synthroid.

Expert tips for using Euthyrox

  • Make sure your health history is accurate. Tell your prescribing healthcare provider about any other prescription drugs or over-the-counter supplements that you take or medical conditions that you have, especially heart disease or adrenal insufficiency.

  • Euthyrox should be taken by mouth in the morning, preferably around the same time each day. It should be taken on an empty stomach with a full glass of water, 30 minutes to one hour before any other foods or medications.

  • Take Euthyrox four hours before or after calcium-containing products or iron because they may reduce its effectiveness.

  • It may take weeks before Euthryox’s effects are noticeable. Keep taking it, and do not abruptly stop taking it.

  • Euthyrox’s dosage may need to be adjusted a few times before finding the best daily dose for each person. Doses that are too high may cause symptoms of hyperthyroidism, such as irregular or increased heart rate, weight loss, sweating, and hyperactivity.

What form(s) does Euthyrox come in

  • Tablet

    • 25 mcg

    • 50 mcg

    • 75 mcg

    • 88 mcg

    • 100 mcg

    • 112 mcg

    • 125 mcg

    • 137 mcg

    • 150 mcg

    • 175 mcg

    • 200 mcg

What are common Euthyrox doses?

Common Euthyrox prescriptions

  • Euthyrox
    30 tablets, 100 mcg box of 30

  • Euthyrox
    30 tablets, 112 mcg box of 30

  • Euthyrox
    30 tablets, 125 mcg box of 30

  • Euthyrox
    30 tablets, 137 mcg box of 30

  • Euthyrox
    30 tablets, 150 mcg box of 30

  • Euthyrox
    30 tablets, 175 mcg box of 30

  • Euthyrox
    30 tablets, 200 mcg box of 30

  • Euthyrox
    30 tablets, 25 mcg box of 30

  • Euthyrox
    30 tablets, 50 mcg box of 30

  • Euthyrox
    30 tablets, 75 mcg box of 30

  • Euthyrox
    30 tablets, 88 mcg box of 30

  • Euthyrox
    90 tablets 25 mcg box of 90

  • Euthyrox
    90 tablets, 100 mcg box of 90

  • Euthyrox
    90 tablets, 112 mcg box of 90

  • Euthyrox
    90 tablets, 125 mcg box of 90

  • Euthyrox
    90 tablets, 137 mcg box of 90

  • Euthyrox
    90 tablets, 150 mcg box of 90

  • Euthyrox
    90 tablets, 175 mcg box of 90

  • Euthyrox
    90 tablets, 200 mcg box of 90

  • Euthyrox
    90 tablets, 50 mcg box of 90

  • Euthyrox
    90 tablets, 75 mcg box of 90

  • Euthyrox
    90 tablets, 88 mcg box of 90

How to take Euthyrox

  • Your doctor will tell you how much to take and how often.

  • Take your medicine at the same time every day.

  • Take this medicine in the morning on an empty stomach, at least 30 to 60 minutes before eating breakfast.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. You may have to take this medicine for four to eight weeks before your symptoms start to get better.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not stop taking this medicine without first checking with your doctor, you may need to take smaller and smaller doses before completely stopping the medicine.

  • If you are giving this medicine to a baby or child who cannot swallow the tablet whole, crush the tablet and mix it in 1 to 2 teaspoons (5 to 10 milliliters) of water. Give the mixture right away using a spoon or dropper. Do not mix the tablet with any other liquid except water. Do not store the mixture for future use.

  • If you miss a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and take a regular dose at the next scheduled time. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Euthyrox

  • Take the missed dose as soon as possible.

  • Skip the missed dose if it is almost time for your next regular dose.

  • You should not take two doses at the same time.

Euthyrox contraindications

  • This medicine is not right for everyone. Do not use Euthyrox if you have:

    • Had an allergic reaction to levothyroxine or glycerol

    • An uncorrected adrenal gland problem

    • A cardiac condition or have had a recent heart attack

    • Had an allergic reaction to any type of thyroid hormone

    • An overactive thyroid gland.

Euthyrox warnings

  • Check with your doctor before taking this medicine if you have a heart or blood vessel disease, high blood pressure, diabetes, kidney disease, liver disease, anemia, blood clotting problems, osteoporosis, or an underactive adrenal or pituitary gland.

  • Tell your doctor if you are pregnant or breastfeeding.

  • Tell your doctor if you have recently received radiation treatment with iodine.

  • Large doses of thyroid hormones, especially when taken with diet pills, can result in dangerous side effects, such as:

    • Inability to tolerate heat

    • Extreme nervousness or irritability

    • Tremors

    • Severe diarrhea

    • Intense sweating

  • Make sure you see your doctor for regular check-ups so that your condition can be followed closely. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause heart problems, including angina (chest pain) and heart arrhythmias, and low bone density

  • This medicine should not be used to treat obesity or as part of a treatment plan for a weight control program.

  • Tell any doctor or dentist who treats you that you are taking this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Euthyrox interactions

  • Some foods and medicines can affect how levothyroxine works. Tell your doctor if you are using any of the following drugs: 

    • Amiodarone

    • Asparaginase

    • Carbamazepine

    • Clofibrate

    • Dexamethasone

    • Digoxin

    • 5-fluorouracil

    • Furosemide

    • Heroin

    • Imatinib

    • Ketamine

    • Methadone, mitotane

    • Nicotinic acid

    • Phenobarbital

    • Phenytoin

    • Rifampin

    • Tamoxifen

    • Beta blockers

    • Birth control pills (including estrogen)

    • Blood thinners (including heparin and warfarin)

    • Insulin or diabetes medicine

    • Antidepressants (including amitriptyline and maprotiline)

    • NSAIDs

    • Salicylates

    • Steroids (including dexamethasone, androgens, and anabolic steroids)

    • Products used for colds, asthma, appetite control, hay fever, or sinus problems

  • In order to lessen the impact of drug interactions with Euthyrox, take the following medications at least four hours before or four hours after you take Euthyrox:

    • Kayexalate

    • Lanthanum

    • Orlistat

    • Sevelamer

    • Sucralfate

    • Antacids (including aluminum or magnesium hydroxide and simethicone)

    • Medicine to lower cholesterol (including cholestyramine, colesevelam, and colestipol)

    • Stomach medicine (including lansoprazole, omeprazole, and pantoprazole)

    • Any medicine that contains calcium or iron

  • Cottonseed meal, dietary fiber, soybean flour (infant formula), or walnuts may decrease the absorption of this medicine. Talk with your doctor if you have questions.

  • Do not eat grapefruit or drink grapefruit juice while you are taking this medicine.

Euthyrox side effects

Euthyrox has some possible side effects. Fortunately, most of them are able to be resolved by lowering the daily dose of Euthyrox. However, there are a few side effects that warrant a visit to a healthcare provider. Seek medical help right away if you experience an allergic reaction, trouble breathing, severe chest pain, or swelling of the face, tongue, or legs. Talk to your doctor if you experience any other side effects, especially if you notice any heart irregularities. 

Serious side effects:

  • Seizures or tremors

  • Fast, pounding, or irregular heartbeat

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain that may spread

  • Fainting

  • Confusion

  • Swelling of the face, tongue, or lower legs

  • Feeling cold

  • Unusual tiredness or weakness

  • Dizziness or lightheadedness

  • Stomach pain

  • Walking with a limp from knee or hip pain (in children)

  • Severe headache, blurred or double vision, nausea, or vomiting (in children)

  • Skin rash or hives

  • Shortness of breath or trouble breathing

  • Inability to tolerate heat

  • Extreme nervousness or irritability

  • Tremors

  • Severe diarrhea

  • Intense or unusual sweating

Less serious side effects:

  • Anxiety

  • Irregular menstrual periods

  • Headache

  • Trouble sleeping

  • Hair loss

  • Appetite or weight changes

  • Diarrhea

  • Muscle spasms or weakness

  • Nervousness

  • Sensitivity to heat

Sources:

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.

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