Alopecia areata is an autoimmune disorder. The immune system attacks hair follicles during their growth phase, causing them to fall out in small patches. During a flare-up, hair will fall out in clumps, leaving a bald patch the size of a quarter or a half dollar, usually on the scalp or face. However, hair can fall out anywhere on the body. In many cases, the hair eventually grows back. Most people will eventually experience another episode of hair loss. The course of the disorder is unpredictable. Some people with alopecia areata may have only one or two episodes of hair loss throughout their lives. But 14% to 25% of people with alopecia areata will eventually lose all the hair on their scalp or body. Fingernails and toenails can also be affected. The nails can become pitted, ridged, or discolored.
RELATED: What causes alopecia? Diagnosis, prevention, and treatment
Alopecia areata is a rare health condition that can affect anyone regardless of age, sex, race, or ethnicity.
Early signs of alopecia areata include sudden patchy hair loss.
Symptoms of alopecia areata do not require immediate medical attention.
Alopecia areata is caused by the immune system attacking hair follicles in their growth stage. You may be at risk for developing alopecia areata symptoms if you have family members with alopecia areata. Other risk factors include autoimmune conditions such as psoriasis, vitiligo, lupus, rheumatoid arthritis, and inflammatory bowel disease (IBD).
Alopecia areata usually requires a medical diagnosis.
Treatment can help shorten flare-ups and promote hair growth. Non-treatment is a viable option. Alopecia areata symptoms due to flare-ups typically resolve with treatment within three months, but not always.
Treatment of alopecia areata may include immunotherapy with corticosteroids or immunosuppressants. Hair regrowth medicines are also a treatment option. Read more about hair loss treatments here.
Alopecia areata is an unpredictable disorder without health-threatening complications. Untreated alopecia areata could result in complications like permanent hair loss, complete hair loss, or mental health disorders.
Use coupons for alopecia areata treatments like Rogaine (minoxidil), triamcinolone, and Xeljanz (tofacitinib) to save up to 80%.
The early signs of alopecia are patchy hair loss, usually on the scalp. They are usually round or oval in shape and about the size of a quarter. There may be one, two, or more small spots on the scalp.
Alopecia areata primarily affects the hair but can also affect fingernails and toenails.
Hair symptoms primarily consist of patchy hair loss. There are several courses the disease can take:
Some people may have only one or a few episodes involving a few patches on the hair or scalp, though other places can be affected. New hair regrows in a few months to a year, and flare-ups rarely recur.
Some people may have multiple skin areas affected, and flare-ups are regular. Small bald patches may be joined by other bald patches so that larger areas of the scalp or the body are hairless. Hair often regrows on some of these patches, but hair loss may be permanent in some affected areas.
In some cases, alopecia areata affects the entire scalp or body, progressing to total loss of hair. Less than 10% of those with total hair loss show some recovery.
Nail symptoms occur in 10% to 15% of cases. Affected nails can be pitted, ridged, brittle, or discolored. Nail symptoms are more common in people who experience extensive hair loss.
RELATED: Why is my hair falling out? Learn the causes of hair loss
Male-pattern and female-pattern baldness, called androgenic alopecia, are easily distinguished from alopecia areata. Patterned baldness typically involves just the top of the head. Hair thins gradually, usually taking years or decades to progress. On the other hand, alopecia areata causes patchy and unpredictable hair loss. The hair can fall out anywhere on the head or the rest of the body. During flare-ups, hair falls out suddenly and in clumps. It can often grow back in a few months to a year, a marked difference from male-pattern or female-pattern baldness.
Alopecia areata | Androgenic alopecia | |
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There is only one type of alopecia areata, but people can experience different degrees of severity. Treatment will depend on the severity, so clinicians generally classify alopecia areata as mild, moderate, or severe, but there’s no agreed-upon scale. One generally accepted scale classifies the severity of alopecia areata based on the amount of skin affected:
Mild alopecia areata involves less than 20% of the scalp
Moderate alopecia areata involves 21% to 49% of the scalp
Severe alopecia areata involves more than half the scalp
Very severe alopecia areata involves the entire scalp
Clinicians also classify alopecia based on the extent and location of hair loss:
Patchy alopecia areata is patchy hair loss on the head or body
Alopecia totalis describes a total loss of scalp hair
Alopecia universalis involves a total loss of body hair
Diffuse alopecia areata involves sudden hair thinning all over the head
Ophiasis alopecia is the loss of hair along a band on the sides or back of the head
Patchy or rapid hair loss is a possible symptom of other medical conditions, so see a doctor when hair starts to fall out without an explanation. Alopecia areata is not a health-threatening medical condition, but treatment can shorten flare-ups and increase the likelihood that new hair will grow back in the affected area. Unless there are other severe symptoms, hair loss does not warrant a trip to the emergency room.
A healthcare professional diagnoses alopecia areata primarily through a medical history and examination of the affected skin. Some people may be referred to a dermatologist for a more detailed evaluation or treatment. In taking a medical history, the clinician will be most interested in the hair loss symptoms. When did they start? Did the hair fall out in clumps or gradually? Where did the hair fall out? The clinician will want to know about medications being taken, hair products being used, family history of hair loss, and any history of autoimmune diseases. The clinician will also ask if you pull at your hair as a nervous habit.
When examining patches of hair loss, the clinician will look for “exclamation point” hairs around the edges of the bald spot. These are hairs that are thin at the roots and are a telltale sign of active alopecia areata. The clinician will also examine the fingernails and toenails to look for pitting or discoloration. They may order other tests, such as blood tests, skin biopsy, or culture.
The complications of alopecia areata involve mental health and social concerns. The most likely complications of alopecia areata are stress, depression, anxiety, and social withdrawal.
Alopecia areata treatment focuses on modulating or suppressing the immune system:
Topical and injected corticosteroids suppress the inflammatory response in the area affected. Both are considered first-line treatments for active alopecia areata. Steroid injections are particularly successful—most people will experience new hair growth in 12 weeks.
Immunosuppressant creams or gels may be used in people experiencing flare-ups with more extensive hair loss. Hair regrowth occurs in more than half of people getting topical immunosuppressants for extensive alopecia areata.
Severe alopecia areata flare-ups may be treated with oral corticosteroids, immunosuppressants, and JAK inhibitors like Xeljanz (tofacitinib) or Olumiant (baricitinib), the first drug FDA-approved to treat alopecia areata.
A significant fraction of people with alopecia areata also have eczema or atopic dermatitis, so eczema or atopic dermatitis treatments such as Dupixent (dupilumab) may also be used.
Hair regrowth drugs like Rogaine (minoxidil) are a treatment option after a flare-up.
RELATED: Hair loss treatments and medications
Alopecia areata is a lifelong condition. Living with alopecia areata means taking care of your physical and mental health with special attention to your hair and scalp.
To keep your hair and scalp healthy:
Eat a healthy diet
Consider supplements such as iron, biotin, riboflavin, folate, vitamin B12, and vitamin D
Manage stress
Wear sunscreen, hats, scarves, or wigs on the head when exposed to the sun
To keep yourself healthy:
Follow medical advice in scheduling physicals—people with alopecia areata are more likely to develop other disorders such as thyroid disease or other autoimmune conditions
Protect your head from the cold
Join a support group
See a mental health professional to help with social and emotional symptoms that may occur with the condition
During an active bout with alopecia areata, hair falls out in patches. The first time this happens, see a healthcare professional. It may be alopecia areata, or it may be a more worrisome medical condition. Once a diagnosis is made, treatment decisions are yours to make. Treatment can help restore hair after flare-ups, but there are side effects. Remember that alopecia areata does not make people sick, so it doesn’t need to impair or interfere with your life.
Most alopecia areata episodes last from a few months to less than a year. The hair usually grows back, but it can be unpredictable.
There is much advice but little conclusive research about the relationship between diet and alopecia areata flare-ups. Research has not definitively found specific foods that precipitate alopecia areata episodes. However, since alopecia areata is an inflammatory disorder, healthcare professionals believe that foods that cause an inflammatory response may bring on or worsen alopecia areata. That’s why some healthcare providers may suggest avoiding inflammatory foods like processed foods, sugar, dairy, or gluten.
During active alopecia areata, hair will fall out, usually in patches. It may occur in one or several places on the scalp or body. The telltale sign of active alopecia areata is the presence of “exclamation point” hairs on the margins of the bald patch. They look like normal hair except for the part of the hair that is right near the scalp. They will be very thin there like they’re barely attached to the scalp. During an examination, a clinician will look for this telltale sign of active alopecia areata.
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Alopecia areata: diagnosis, treatment, and steps to take, NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Alopecia areata, StatPearls
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Lifestyle factors involved in the pathogenesis of alopecia areata, International Journal of Molecular Sciences
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Eczema treatments and medications, SingleCare
What causes alopecia? Diagnosis, prevention, and treatment, SingleCare
Anne Jacobson, MD, MPH, is a board-certified family physician, writer, editor, teacher, and consultant. She is a graduate of University of Wisconsin School of Medicine and Public Health, and trained at West Suburban Family Medicine in Oak Park, Illinois. She later completed a fellowship in community medicine at PCC Community Wellness and a master's in Public Health at the University of Illinois-Chicago. She lives with her family near Chicago.
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