Valium (generic name: diazepam) is available as an intramuscular injection, intravenous injection, and tablet. It is most commonly prescribed and taken as a tablet.
Tablet: 2 mg, 5 mg, 10 mg
Intramuscular injection: varies
Intravenous injection: varies
Valium belongs to a group of medications called benzodiazepines, which work by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. The Food and Drug Administration (FDA) has approved Valium to treat anxiety disorders, acute seizures, panic attacks, status epilepticus, and acute alcohol withdrawal. Because of its sedative effects, it can also be used as a sedative before surgery and is sometimes prescribed off-label for sleep terrors, sleepwalking, serotonin syndrome, and confusional arousals.
Valium is safe for many adults, but it is a controlled substance and has the potential to be abused or cause addiction. It may not be the right medication for people with addictive personalities or for those with drug or alcohol problems.
Valium dosage chart | |||
---|---|---|---|
Indication | Starting dosage | Standard dosage | Maximum dosage |
Anxiety | 2-10 mg tablet taken orally 2-4 times per day | 10 mg tablet taken orally 2-4 times daily | |
Preop sedation | 10 mg administered as an intramuscular injection before surgery | ||
Procedural sedation | 5-15 mg administered as an intravenous injection 5-10 minutes before a procedure | ||
Alcohol withdrawal | 10 mg tablet taken orally 3-4 times in the first 24 hours | 5 mg tablet taken orally 3-4 times daily | 10 mg tablet taken orally 3-4 times |
Muscle spasms | 2-10 mg tablet taken 3-4 times daily | ||
Status epilepticus | 5-10 mg administered as an intravenous injection once | 5-10 mg administered intravenously every 10-15 minutes after an initial dose if necessary | 30 mg administered as an intravenous injection |
Source: Epocrates
Valium is only safe for pediatric patients 6 months of age and older to take if approved by a medical doctor. Children have an increased risk of having varied responses to CNS-acting drugs like Valium, so they are almost always started on the lowest dose possible.
Standard dosage for children ages 6 months and older: 0.1-10 mg
Maximum dosage for children ages 6 months and older: 30 mg
Valium dosage by age | ||
---|---|---|
Indication | Age | Recommended dosage |
Anxiety | 6 months to 12 years old | 0.12-0.8 mg/kg per day taken every 6-8 hours |
13+ years old | 2-10 mg tablet taken 2-4 times per day | |
Muscle spasms | 6 months to 12 years old | 0.12-0.8 mg/kg per day taken every 6-8 hours |
13+ years old | 2-10 mg tablet taken 2-4 times per day | |
Status epilepticus | 1 month to 4 years old | 0.1-0.3 mg/kg administered intravenously every 5-10 minutes as needed, not to exceed 5 mg total |
5 to 12 years old | 0.1-0.3 mg/kg administered intravenously every 5-10 minutes as needed, not to exceed 10 mg total | |
13+ years old | 5-10 mg administered intravenously every 10-15 minutes as needed, not to exceed 30 mg total |
People with certain medical conditions may need to have their dose of diazepam adjusted to make sure they stay healthy. Valium is contraindicated for patients with renal and hepatic impairment because of its potential to cause adverse effects such as metabolite accumulation.
In addition to renally and hepatically impaired patients, people with one or more of the following may need restricted daily doses of Valium to avoid adverse reactions:
Pulmonary impairment
Sleep apnea
Central nervous system depression
Depression
Suicidal thoughts or behavior
Porphyra (build up of porphyrin that binds to hemoglobin)
Liver disease
Myasthenia gravis
Acute narrow-angle glaucoma
Breathing problems
History of drug or alcohol abuse or addiction
Valium is used to treat anxiety, lack of appetite, tense muscles, and seizures in cats, dogs, horses, birds, small mammals, and exotic species. The exact amount of Valium animals need will vary based on what kind of animal they are and their specific medical condition, so it’s always best to consult with a veterinarian.
Taking Valium correctly is the best way to make sure it’s as effective as possible. Here’s how to take it:
Follow the directions on the prescription label and read all medication guides closely. Your doctor may occasionally change your dose. Never take Valium in larger amounts or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.
Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Drug misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. It’s illegal to sell or give away this medicine.
Valium should only be used for a short time. Do not take this medicine for longer than four months without your doctor's advice.
Do not stop using Valium suddenly, even if you feel fine. Stopping suddenly increases the risk of seizures or unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
Taking Valium correctly will not only ensure it works as well as it can, but it’s also the best way to avoid common side effects such as:
Drowsiness
Muscle weakness
Constipation
Fatigue
Dizziness
Blurred vision
Ataxia ( problems with balance and muscle movement)
Although it’s rare, Valium can cause more serious side effects that can become life-threatening. Some people will have allergic reactions to Valium that cause trouble breathing, hives, and swelling of the face, throat, or neck. If this happens to you, seek emergency medical care right away.
Valium also comes with a black box warning because it’s easily abused, misused, and can be highly addictive. Taking Valium at the same time as other antidepressants or opioids can cause profound sedation, hypotension, respiratory depression, coma, and death. This is why it’s so important to talk with a doctor before taking Valium and to take it correctly.
Valium can start to work within several minutes if it’s injected and within an hour if it’s taken orally. Aside from drug form, other factors like a patient's weight, level of physical activity, diet, and use of other medications can affect how quickly Valium starts working. The best way to know how quickly Valium will start working for you is to talk with a healthcare professional.
Valium has a half-life of about 30-56 hours, which means that a single dose of the drug will be halfway gone from the body in that amount of time. It can take almost 10 days for a single dose of Valium to be completely eliminated from the body if no other doses are taken.
If you miss a dose of Valium, take the missed dose as soon as you remember, unless it’s almost time to take your next dose. Never take two doses at one time because this could cause an overdose.
Valium is only meant to be taken for a short period of time. Most people will only take the medication for about two to four weeks. It shouldn’t be taken for more than four months without a doctor’s approval.
Valium should never be stopped abruptly because it can cause seizures and other withdrawal symptoms. If Valium isn’t working for you or causing you to experience too many side effects, your doctor can work with you to taper you off the drug. You might want to consider alternatives to Valium like Prozac (fluoxetine), Elavil (amitriptyline), or Nardil (phenelzine).
The maximum dosage for Valium will vary based on the medical condition being treated and the age of the patient. The maximum dosage ranges from 10 to 30 mg for adults and 0.2 to 30 mg for kids.
It’s possible to overdose on Valium. Overdosing can cause serious side effects like extreme drowsiness, limp or weak muscles, slow breathing, loss of coordination, and coma. Overdosing on Valium can be fatal if it’s taken with opioid medications, alcohol, or drugs that cause drowsiness or slow down breathing.
Seek medical advice right away if you’ve overdosed or think you’ve overdosed on Valium. Call the Poison Help line at 1-800-222-1222 or go to the emergency room as soon as possible.
Valium shouldn’t be taken alongside certain prescription drugs because of the potential for adverse drug interactions. Do not take Valium with:
Amifampridine
Barbiturates
Muromonab-CD3
MAO inhibitors
CNS depressants like phenothiazines and antihistamines
It’s not safe to consume alcohol while taking Valium. As a standalone drug, Valium has the potential to cause respiratory depression and slow or stop your breathing. When it’s taken at the same time as alcohol, it’s even more likely to cause breathing problems that can be fatal.
Misusing Valium can cause addiction, overdoses, and death. It’s extremely important to take Valium exactly as prescribed and to follow your healthcare provider’s guidelines.
Valium should only be taken during pregnancy if approved by a medical doctor. If you take Valium while pregnant, your baby could develop a physical dependence on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
Do not breastfeed while using this medicine. Valium passes into breast milk during lactation and may be harmful to infants.
Valium patient education, Epocrates
How long does Valium stay in your system, American Addiction Centers
Diazepam, VCA
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
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