What is Sulfamethoxazole-Trimethoprim: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 30, 2020

Sulfamethoxazole-Trimethoprim overview

BRAND NAMES:

  • Bactrim, Bactrim DS, SMZ-TMP Pediatric, Sulfatrim Pediatric, Sulfatrim Pediatric, Sulfatrim Pediatric

Generic Names:

  • Sulfamethoxazole-Trimethoprim

Uses:

  • Treats or prevents infections.

Therapeutic Classes:

  • Antibiotic, Sulfonamide Combination

Forms:

  • Liquid, Tablet

How it’s taken:

  • By mouth

What is Sulfamethoxazole-Trimethoprim used for?

Sulfamethoxazole-Trimethoprim is an antibiotic that is used to treat and prevent bacterial infections, including ear infections, urinary tract infections and other conditions as prescribed by your doctor. It works by stopping the growth of bacteria. Sulfamethoxazole-Trimethoprim should not be used to treat other types of infections. It is indicated for use by adults and children 2 months and older. It is available as a liquid.

What form(s) does Sulfamethoxazole-Trimethoprim come in

  • Liquid

  • Tablet

What are common Sulfamethoxazole-Trimethoprim doses?

  • Tablet 400-80MG

  • Tablet 800-160MG

  • Bottle 473ML of 200-40MG/5ML

  • Cup 20ML of 200-40MG/5ML

  • Vial 5ML of 400-80MG/5ML

  • Vial 10ML of 400-80MG/5ML

  • Vial 30ML of 400-80MG/5ML

Common Sulfamethoxazole-Trimethoprim prescriptions

  • Sulfamethoxazole-Trimethoprim
    473ml of 200-40mg/5ml bottle

  • Sulfamethoxazole-Trimethoprim
    400-80mg tablet

  • Sulfamethoxazole-Trimethoprim
    800-160mg tablet

  • Sulfamethoxazole-Trimethoprim
    10ml of 400-80mg/5ml vial

  • Sulfamethoxazole-Trimethoprim
    30ml of 400-80mg/5ml vial

  • Sulfamethoxazole-Trimethoprim
    5ml of 400-80mg/5ml vial

How to take Sulfamethoxazole-Trimethoprim

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

Sulfamethoxazole-Trimethoprim contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to trimethoprim, sulfamethoxazole, or any sulfa drug. Do not use this medicine if you are pregnant, if you have kidney disease, liver disease, anemia caused by low levels of folic acid, or if you have a history of drug-induced thrombocytopenia.

Sulfamethoxazole-Trimethoprim warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have diabetes, malabsorption or malnutrition, folate deficiency, G6PD deficiency, porphyria, thyroid problems, or a history of alcoholism. Tell your doctor if you have asthma or severe allergies, especially if you are allergic to any medicines. It is important for your doctor to know if you have HIV or AIDS, because this medicine might work differently for you.

  • This medicine may cause the following problems: Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), or acute febrile neutrophilic dermatosis (AFND)Liver problemsHypoglycemia (low blood sugar)

  • This medicine lowers the number of certain blood cells, so you may bleed or bruise more easily. Be careful to avoid injuries.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Sore throat, fever, muscle pain

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Uneven heartbeat, numbness or tingling in your hands, feet, or lips

  • Unusual bleeding, bruising, or weakness

Sulfamethoxazole-Trimethoprim interactions

  • Do not use this medicine if you are also using dofetilide. Do not use this medicine for Pneumocystis jiroveci pneumonia (PCP) if you are also using leucovorin.

  • Some medicines can affect how this medicine works. Tell your doctor if you also use the following: Amantadine, cyclosporine, digoxin, indomethacin, memantine, methotrexate, phenytoin, procainamide, pyrimethamine, warfarin, zidovudineBlood pressure medicine (including an ACE inhibitor)Diabetes medicine (including glipizide, glyburide, metformin, pioglitazone, repaglinide, rosiglitazone)Diuretic (water pill, including hydrochlorothiazide)Medicine to treat depression (including TCAs)

  • This medicine may cause a severe allergic reaction.

  • This medicine may lower the number of platelets in your body, which are necessary for proper blood clotting. This may cause you to bleed or get infections more easily. Talk with your doctor if you have concerns about this.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Sulfamethoxazole-Trimethoprim side effects

Serious Side Effects

  • Skin rash, purple spots on your skin, or very pale or yellow skin

  • Unusual bleeding or bruising

  • Blistering, peeling, or red skin rash

  • Chest pain, cough, or trouble breathing

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Uneven heartbeat, numbness or tingling in your hands, feet, or lips

  • Severe diarrhea, stomach pain, cramps, bloating

  • Change in how much or how often you urinate, painful urination, lower back or side pain

  • Confusion, weakness, muscle twitching, seizures

  • Sore throat, fever, muscle pain

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Headache