What is Nexium: Uses, Warnings & Interactions

Updated Jan. 13, 2021  •  Published Dec. 30, 2020

Nexium overview

BRAND NAMES:

  • Pharmapure RX Esomep-EZS, NexIUM 24HR ClearMinis, NexIUM 24HR, Good Sense Esomeprazole Magnesium, NexIUM, Sunmark Esomeprazole Magnesium, Sunmark Esomeprazole Magnesium, Sunmark Esomeprazole Magnesium

Generic Names:

  • Esomeprazole Magnesium

Uses:

  • Treats gastroesophageal reflux disease (GERD), a damaged esophagus, and conditions that cause your stomach to make too much acid, including Zollinger-Ellison syndrome. Also treats and prevents stomach ulcers. This medicine is a proton pump inhibitor (PPI).

Therapeutic Classes:

  • Gastric Acid Secretion Inhibitor, Gastrointestinal Agent

Forms:

  • Delayed Release Capsule, Packet

How it’s taken:

  • By mouth

What is Nexium used for?

Nexium is a medication used to treat problems with the stomach ulcers and acid reflux. Nexium belongs to a class of drugs called proton pump inhibitors. The drug decreases the amount of acid your stomach makes. Nexium is a brand name for the drug esomeprazole. Nexium was first introduced in 2001, and the drug is now available over the counter. In the treatment of stomach ulcers and acid reflux, Nexium use is common.

What form(s) does Nexium come in

  • Delayed Release Capsule

  • Packet

What are common Nexium doses?

  • Capsule Delayed Release 20MG

  • Capsule Delayed Release 40MG

  • Packet 10MG

  • Packet 20MG

  • Packet 40MG

Common Nexium prescriptions

  • NexIUM
    30 capsules delayed release bottle

  • NexIUM
    60 capsules delayed release bottle

  • NexIUM
    90 capsules delayed release bottle

  • NexIUM
    20mg capsule delayed release

  • NexIUM
    40mg capsule delayed release

  • NexIUM
    10mg packet

  • NexIUM
    2.5mg packet

  • NexIUM
    20mg packet

  • NexIUM
    40mg packet

  • NexIUM
    5mg packet

How to take Nexium

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Take all of the medicine in your prescription, even if you feel better after a few days.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Take this medicine at least 1 hour before a meal.

  • Delayed-release capsule: Swallow the capsule whole. Do not crush or chew it.If you cannot swallow the capsule, you may mix its contents into 1 tablespoon of applesauce. Stir the mixture well and swallow it right away. Do not chew. Throw away any remaining mixture.

  • Packets: 2.5- or 5-milligram (mg) packet: Mix with 1 teaspoon (5 milliliters [mL]) of water and stir well.10-, 20-, or 40-mg packet: Mix with 1 tablespoon (15 mL) of water and stir well.Let the mixture thicken for 2 to 3 minutes. Stir once more, and drink within 30 minutes. Add more water to any leftover medicine and drink it right away.

  • Feeding tube: Capsule contents: Open the capsule and pour the contents into a 60-mL catheter-tipped syringe. Pour 50 mL of water into the syringe. Do not use any other liquids or syringes.Place the syringe plunger back into the syringe and shake well for 15 seconds. Make sure no medicine is stuck in the tip of the syringe. Inject the medicine into the NG tube right away.Use water to rinse any leftover medicine through the tube.Packet contents: 2.5- or 5-mg packets: Add 5 mL (1 teaspoon) of water into a catheter-tipped syringe. Pour the 2.5- or 5-mg packet into the syringe, shake well right away, and let the medicine thicken for 2 to 3 minutes.10-, 20-, or 40-mg packets: Add 15 mL (1 tablespoon) of water into a catheter-tipped syringe. Pour the 10-, 20-, or 40-mg packet into the syringe, shake well right away, and let the medicine thicken for 2 to 3 minutes.Shake the thickened mixture once more, and inject the medicine into the tube within 30 minutes.Refill the syringe with the same amount of water that was used in the mixture (5 or 15 mL). Shake it gently, and inject it into the tube to rinse any leftover medicine through the tube.This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one. Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Take all of the medicine in your prescription, even if you feel better after a few days.

  • Delayed-release capsule: Swallow the capsule whole. Do not crush or chew it.If you cannot swallow the capsule, you may mix its contents into 1 tablespoon of applesauce. Stir the mixture well and swallow it right away. Do not chew. Throw away any remaining mixture.

  • Packets: 2.5- or 5-milligram (mg) packet: Mix with 1 teaspoon (5 milliliters [mL]) of water and stir well.10-, 20-, or 40-mg packet: Mix with 1 tablespoon (15 mL) of water and stir well.Let the mixture thicken for 2 to 3 minutes. Stir once more, and drink within 30 minutes. Add more water to any leftover medicine and drink it right away.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Feeding tube: Capsule contents: Open the capsule and pour the contents into a 60-mL catheter-tipped syringe. Pour 50 mL of water into the syringe. Do not use any other liquids or syringes.Place the syringe plunger back into the syringe and shake well for 15 seconds. Make sure no medicine is stuck in the tip of the syringe. Inject the medicine into the NG tube right away.Use water to rinse any leftover medicine through the tube.Packet contents: 2.5- or 5-mg packets: Add 5 mL (1 teaspoon) of water into a catheter-tipped syringe. Pour the 2.5- or 5-mg packet into the syringe, shake well right away, and let the medicine thicken for 2 to 3 minutes.10-, 20-, or 40-mg packets: Add 15 mL (1 tablespoon) of water into a catheter-tipped syringe. Pour the 10-, 20-, or 40-mg packet into the syringe, shake well right away, and let the medicine thicken for 2 to 3 minutes.Shake the thickened mixture once more, and inject the medicine into the tube within 30 minutes.Refill the syringe with the same amount of water that was used in the mixture (5 or 15 mL). Shake it gently, and inject it into the tube to rinse any leftover medicine through the tube.This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one. Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take this medicine at least 1 hour before a meal.

Nexium contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to esomeprazole or similar medicines.

Nexium warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, vitamin B12 deficiency, or osteoporosis.

  • This medicine may cause the following problems:Kidney problemsIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Stomach pain, nausea, vomiting, weight loss, bloody or black stools

Nexium interactions

  • Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following:Atazanavir, cilostazol, diazepam, digoxin, erlotinib, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, rifampin, saquinavir, St John's wort, tacrolimus, voriconazoleBlood thinner (including clopidogrel or warfarin)Diuretic (water pill)Iron supplements

  • This medicine may cause the following problems:Kidney problemsBroken bones in the hip, wrist, or spineLow levels of vitamin B12 or magnesium in the blood

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Nexium side effects

Serious Side Effects

  • Severe diarrhea that does not go away

  • Fever, joint pain, swelling in your body, unusual weight gain, changes in how much or how often you urinate

  • Joint pain, rash on your cheeks or arms that gets worse in the sun

  • Stomach pain, nausea, vomiting, weight loss, bloody or black stools

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Fast, pounding, or uneven heartbeat

  • Seizures, dizziness, muscle cramps, twitching

Less Serious Side Effects

  • Mild diarrhea, constipation, or gas

  • Headache