What is Protonix: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 30, 2020

Protonix overview

BRAND NAMES:

  • Protonix, Amerinet Choice Protonix IV, PremierPro Rx Protonix IV, Protonix, Protonix IV, Protonix Novaplus

Generic Names:

  • Pantoprazole Sodium

Uses:

  • Treats gastroesophageal reflux disease (GERD), a damaged esophagus, and conditions that cause your stomach to make too much acid, including Zollinger-Ellison syndrome. This medicine is a proton pump inhibitor (PPI)., Treats gastroesophageal reflux disease (GERD), a damaged esophagus, and conditions that cause your stomach to make too much acid, including Zollinger-Ellison syndrome. This medicine is a proton pump inhibitor (PPI).

Therapeutic Classes:

  • Gastric Acid Secretion Inhibitor, Gastric Acid Secretion Inhibitor

Forms:

  • Injectable, Packet, Tablet, Delayed Release Tablet, Long Acting Tablet

How it’s taken:

  • By mouth, By injection

What form(s) does Protonix come in

  • Injectable

  • Packet

  • Tablet

  • Delayed Release Tablet

  • Long Acting Tablet

What are common Protonix doses?

  • Packet 40MG

  • Tablet Delayed Release 20MG

  • Tablet Delayed Release 40MG

  • Solution Reconstituted 40MG

Common Protonix prescriptions

  • Protonix
    30 tablets delayed release bottle

  • Protonix
    40mg packet

  • Protonix
    40mg solution reconstituted

  • Protonix
    20mg tablet delayed release

  • Protonix
    40mg tablet delayed release

How to take Protonix

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it.

  • Delayed-release packet: Take the medicine mixed in apple juice or applesauce at least 30 minutes before a meal. It may also be given using a nasogastric tube when mixed in apple juice only.To prepare with applesauce: Mix the packet contents with 1 teaspoon of applesauce. Do not mix with water or other liquids or food. Do not divide the packet contents to make smaller doses.Swallow the mixture within 10 minutes after you mix it. Do not chew or crush the granules.Sip some water after you take the mixture to make sure you swallow all of the medicine.To prepare with apple juice: Mix the packet contents with 1 teaspoon of apple juice in a small cup. Do not divide the packet contents to make smaller doses.Stir for 5 seconds and drink the mixture immediately. Do not chew or crush the granules.To make sure you get all of the medicine, add more apple juice to the cup. Drink it immediately.To prepare for a feeding tube: Pour the packet contents in a 2-ounce (60 milliliter [mL]) catheter-tip syringe.Add 10 mL of apple juice to the syringe. Add the mixture to the tube. Gently tap or shake the barrel of the syringe to help empty it.Add 10 mL of apple juice to the syringe and put it in the tube. Do this at least 2 times. There should be no granules left in the syringe.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Delayed-release packet: Take the medicine mixed in apple juice or applesauce at least 30 minutes before a meal. It may also be given using a nasogastric tube when mixed in apple juice only.To prepare with applesauce: Mix the packet contents with 1 teaspoon of applesauce. Do not mix with water or other liquids or food. Do not divide the packet contents to make smaller doses.Swallow the mixture within 10 minutes after you mix it. Do not chew or crush the granules.Sip some water after you take the mixture to make sure you swallow all of the medicine.To prepare with apple juice: Mix the packet contents with 1 teaspoon of apple juice in a small cup. Do not divide the packet contents to make smaller doses.Stir for 5 seconds and drink the mixture immediately. Do not chew or crush the granules.To make sure you get all of the medicine, add more apple juice to the cup. Drink it immediately.To prepare for a feeding tube: Pour the packet contents in a 2-ounce (60 milliliter [mL]) catheter-tip syringe.Add 10 mL of apple juice to the syringe. Add the mixture to the tube. Gently tap or shake the barrel of the syringe to help empty it.Add 10 mL of apple juice to the syringe and put it in the tube. Do this at least 2 times. There should be no granules left in the syringe.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Your doctor will give you a few doses of this medicine until your condition improves and then switch you to an oral medicine that works the same way. Talk to your doctor if you have concerns about this.

  • Your doctor will give you a few doses of this medicine until your condition improves and then switch you to an oral medicine that works the same way. Talk to your doctor if you have concerns about this.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

Protonix contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to pantoprazole or similar medicines.

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to pantoprazole or similar medicines.

Protonix warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, osteoporosis, or zinc deficiency.

  • This medicine may cause the following problems:Serious skin reactionsKidney problemsIncreased risk of broken bones in the hip, wrist, or spine (more likely if received several times per day or longer than 1 year)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Seizures, dizziness, muscle cramps, or twitching

  • Severe diarrhea that does not go away, stomach pain, nausea, vomiting, and fever

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, or osteoporosis.

  • This medicine may cause the following problems:Kidney problemsIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Protonix interactions

  • Do not use pantoprazole together with medicine that contains rilpivirine.

  • Some medicines can affect how pantoprazole works. Tell your doctor if you are using any of the following: Ampicillin, atazanavir, dasatinib, digoxin, erlotinib, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, nilotinib, saquinavirBlood thinner (including warfarin)Diuretic (water pill)Iron supplements

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • You should not receive this medicine together with medicine that contains rilpivirine.

  • Some medicines can affect how pantoprazole works. Tell your doctor if you are using any of the following:Ampicillin, atazanavir, dasatinib, digoxin, erlotinib, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, nilotinib, saquinavirBlood thinner (including warfarin)Diuretic (water pill)Iron supplements

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Protonix side effects

Serious Side Effects

  • Seizures, dizziness, uneven heartbeat, muscle cramps or twitching

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Severe diarrhea, stomach cramp or pain, nausea, vomiting, weight loss

  • Fever, joint pain, swelling in your body, unusual weight gain, change in how much or how often you urinate

  • Joint pain, rash on your cheeks or arms that gets worse in the sun

  • Stomach pain, nausea, vomiting, weight loss

  • Fast, pounding, or uneven heartbeat

  • Pain, tenderness, or swelling in your arm or leg

  • Severe diarrhea that does not go away, stomach pain, nausea, vomiting

  • Joint pain, rash on your cheeks or arms that gets worse in the sun

  • Fever, swelling in your body, unusual weight gain, change in how much or how often you urinate

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Seizures, dizziness, muscle cramps, twitching

Less Serious Side Effects

  • Headache

  • Redness, pain, itching, swelling, or a lump under your skin where the needle is placed

  • Headache