What is Clarithromycin: Uses, Warnings & Interactions

Updated Jan 12, 2021  •  Published Dec 30, 2020

Clarithromycin overview

BRAND NAMES:

  • Biaxin, Biaxin Filmtab, Biaxin XL, Prevpac, Prevpac, Triple Therapy

Generic Names:

  • Clarithromycin

Uses:

  • Treats and prevents infections. Also treats duodenal ulcers caused by H pylori. This medicine is a macrolide antibiotic.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Liquid, Tablet, Long Acting Tablet

How it’s taken:

  • By mouth

What is Clarithromycin used for?

Clarithromycin works to block the bacteria from spreading in the body. This macrolide antibiotic is used to treat certain skin bacterial infection and respiratory system. Clarithromycin, when combined with other medication can be very effective in treating Helicobacter pylori caused by stomach ulcers.

What form(s) does Clarithromycin come in

  • Liquid

  • Tablet

  • Long Acting Tablet

What are common Clarithromycin doses?

  • Tablet 250MG

  • Tablet 500MG

  • Bottle 60 Tablets

  • Bottle 50ML of 125MG/5ML

  • Bottle 100ML of 125MG/5ML

  • Bottle 50ML of 250MG/5ML

  • Bottle 100ML of 250MG/5ML

Common Clarithromycin prescriptions

  • Clarithromycin
    100ml of 125mg/5ml bottle

  • Clarithromycin
    100ml of 250mg/5ml bottle

  • Clarithromycin
    50ml of 125mg/5ml bottle

  • Clarithromycin
    50ml of 250mg/5ml bottle

  • Clarithromycin
    60 tablets bottle

  • Clarithromycin
    250mg tablet

  • Clarithromycin
    500mg tablet

How to take Clarithromycin

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.

  • Extended-release tablets: These should be taken with food. Swallow the extended-release tablet whole. Do not break, crush, or chew it.

  • Tablets: These may be taken with or without food. Swallow the tablet whole. Do not break, crush, or chew it.

  • Oral liquid: This may also be taken with or without food. Shake the bottle well before you measure the medicine. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate or freeze the oral liquid. Throw away any leftover oral liquid 14 days after you fill the prescription.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Tablets: These may be taken with or without food. Swallow the tablet whole. Do not break, crush, or chew it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate or freeze the oral liquid. Throw away any leftover oral liquid 14 days after you fill the prescription.

  • Extended-release tablets: These should be taken with food. Swallow the extended-release tablet whole. Do not break, crush, or chew it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.

  • Oral liquid: This may also be taken with or without food. Shake the bottle well before you measure the medicine. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

Clarithromycin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to clarithromycin, erythromycin, or similar medicines, if you have a history of liver problems caused by clarithromycin, or if you are pregnant.

Clarithromycin warnings

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, myasthenia gravis, or a history of porphyria. Tell your doctor if anyone in your family has heart rhythm problems.

  • This medicine may cause the following problems:Serious skin reactionsChanges in heart rhythm (including QT prolongation)Liver problems

  • This medicine may make you dizzy or confused. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. It may occur 2 months or more after you stop using this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Clarithromycin interactions

  • Do not use this medicine if you are also using cisapride, lomitapide, lovastatin, pimozide, simvastatin, or ergot medicines. Do use this medicine together with colchicine if you have kidney or liver disease, or with ranitidine bismuth citrate if you have kidney disease or a history of porphyria.

  • There are many other drugs that can interact with clarithromycin. Make sure your doctor knows about all other medicines you are using. Tell your doctor if you are also using any of the following:Alfentanil, alprazolam, atorvastatin, bromocriptine, cilostazol, colchicine, cyclosporine, digoxin, itraconazole, midazolam, methylprednisolone, omeprazole, phenobarbital, phenytoin, pravastatin, quetiapine, rifabutin, sildenafil, tacrolimus, tadalafil, theophylline, tolterodine, triazolam, valproate, vardenafil, vinblastine, or St John's wortBlood pressure medicineBlood thinner (including warfarin)Insulin or diabetes medicine taken by mouthMedicine for heart rhythm problems (including amiodarone, disopyramide, dofetilide, procainamide, quinidine, sotalol)Medicine to treat HIV or AIDSSeizure medicine (including carbamazepine)

  • If you also take zidovudine, clarithromycin and zidovudine should be taken at least 2 hours apart.

  • If you also take zidovudine, clarithromycin and zidovudine should be taken at least 2 hours apart.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Clarithromycin side effects

Serious Side Effects

  • Blistering, peeling, red skin rash

  • Severe diarrhea that may contain blood

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fast, slow, pounding, or uneven heartbeat, chest pain

  • Severe nausea, vomiting, stomach pain

  • Dark urine, pale stools, loss of appetite, yellow skin or eyes

Less Serious Side Effects

  • Change in taste

  • Mild diarrhea, nausea, vomiting, stomach pain