What is Trintellix: Uses, Warnings & Interactions

Take your medicine as directed. Your dosage may need to be changed several times to find what works best for you.

Take this medicine at the same time each day.

This medicine should come with a medication guide. Ask your pharmacist for a copy if you do not have one.

Do not exceed the dosage prescribed by your healthcare provider.

Consult your doctor or healthcare provider before stopping this medication. The dosage may need to be gradually reduced to prevent withdrawal symptoms. 

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

This medicine is not right for everyone. Do not use it if you have had an allergic reaction to vortioxetine.

Trintellix should not be used within 14 days of stopping a monoamine oxidase inhibitor (MAOI). In addition, MAOIs should not be used with Trintellix or within 21 days of stopping Trintellix. MAOIs include linezolid and methylene blue.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dosage before you stop it completely.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Tell your doctor if you are pregnant or breastfeeding

Tell your doctor if you have any medical conditions, including bleeding problems, bipolar disorder, glaucoma, or low levels of salt or sodium in your blood.

Trintellix carries a boxed warning for children, teenagers, and young adults, as it may lead to an increased risk of suicidal thoughts or behavior. Trintellix is not recommended for children under 18. 

​​Taking Trintellix may raise the risk of developing serotonin syndrome, a potentially life-threatening condition characterized by rapid heart rate, high blood pressure, and increased body temperature.

Trintellix may increase the risk of bleeding events, particularly when taken with other medications known to affect blood clotting, such as NSAIDs, aspirin, or blood thinners.

In patients with bipolar disorder, Trintellix may trigger episodes of mania or hypomania.

Trintellix, like other antidepressants, may cause sexual side effects, which may include decreased libido, delayed ejaculation, or difficulty achieving orgasm.

This medicine may make you dizzy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

Taking an MAOI with Trintellix can increase the risk of serotonin syndrome. Do not take Trintellix within 14 days of stopping an MAOI. Do not take an MAOI within 21 days of stopping Trintellix.

Combining Trintellix with other serotonergic drugs or supplements, such as SSRIs, tricyclic antidepressants, and St. John’s wort, may increase the risk of serotonin syndrome. Other serotonergic drugs include opioids, amphetamines, tryptophan, lithium, buspirone, and certain migraine medications called triptans.  

Taking Trintellix with anticoagulants or blood thinners, such as warfarin, may increase the risk of bleeding. In addition, it’s recommended to use caution with nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen because of their blood-thinning effects. 

Some medicines can affect how Trintellix is processed in the body. Tell your doctor if you are using the following: Carbamazepine, phenytoin, quinidine, rifampin, bupropion, fluoxetine, or paroxetine.