Prozac
Fluoxetine HCl
Treats depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder
Antidepressant, selective serotonin reuptake inhibitor (SSRI), central nervous system agent
Tablet, capsule, delayed-release capsule, oral solution (liquid)
By mouth
Fluoxetine is FDA-approved to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder (PMDD), and binging-purging in people diagnosed with bulimia. It’s also approved for use with the antipsychotic drug Zyprexa (olanzapine) for treatment-resistant depression and depressive episodes in people diagnosed with bipolar I disorder. Its many off-label uses include generalized anxiety disorder, social anxiety disorder, and posttraumatic stress disorder (PTSD).
Tablet
10 mg
20 mg
60 mg
Capsule
20 mg
30 mg
40 mg
Delayed-release capsule
90 mg
Oral solution (liquid)
20 mg/5 mL
For major depressive disorder:
In adults: 20–80 mg taken once daily in the morning
In children ages 6–7: 10 mg taken once daily in the morning
In children ages 8–18: 10–20 mg taken once daily in the morning
For obsessive-compulsive disorder in adults and children ages 7–17: 20–60 mg taken once daily in the morning
For bulimia in adults: 60 mg taken once daily in the morning
For panic disorder in adults: 20 mg taken once daily in the morning
For premenstrual dysphoric disorder in adults: 20 mg taken once daily in the morning
For bipolar I depressive episodes in adults and children 10 years or older: 20–50 mg taken once daily in the morning along with olanzapine
For treatment-resistant depression in adults: 20–50 mg taken once daily in the morning along with olanzapine
FLUoxetine HCl
120ml of 20mg/5ml bottle
FLUoxetine HCl
4 capsules delayed release box
FLUoxetine HCl
10mg capsule
FLUoxetine HCl
20mg capsule
FLUoxetine HCl
40mg capsule
FLUoxetine HCl
10mg tablet
FLUoxetine HCl
20mg tablet
FLUoxetine HCl
60mg tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
This medicine should come with a medication guide. Ask your pharmacist for a copy if you do not have one.
You may need to take this medicine for a month or longer before you feel better. If you feel that the medicine is not working well, tell your doctor right away. Do not take more than your normal dose.
Take fluoxetine doses at the same time each day.
Fluoxetine doses can be taken with or without food.
How to take fluoxetine tablets or capsules
Swallow the tablet or capsule whole with a glass of water.
Store fluoxetine tablets or capsules at room temperature away from light.
How to take fluoxetine oral solution
You do not need to shake the bottle before measuring a dose.
Measure the dose using a calibrated oral syringe or similar calibrated device.
Store fluoxetine oral solution at room temperature away from light.
Fluoxetine should be taken once per day in the morning.
If you miss a dose or forget to take your medicine, take it as soon as you can on the day you were supposed to take it.
If the dose is remembered the next day, just skip the missed dose and take the next dose as scheduled in the morning.
Do not use extra medicine to make up for a missed dose.
This medicine is not right for everyone.
Do not use it if you have had an allergic reaction to fluoxetine.
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
Your doctor may need to do lab tests regularly to check your progress and any effects of the medicine. Keep all appointments.
For some children, teenagers, and young adults, this medicine increases the risk of suicidal thoughts and behaviors. It may worsen depression or emotional problems. Talk with your doctor right away if you notice any thoughts or behavior changes that concern you.
Tell your doctor if you or anyone in your family has a history of bipolar disorder, mania, hypomania, other mental illnesses, or suicide attempts.
Tell your doctor if you are pregnant or breastfeeding.
Tell your doctor if you have:
Kidney disease
Liver disease
Bleeding problems
Diabetes
High blood pressure
Glaucoma
A history of seizures
Heart disease, including heart failure or a history of heart attacks
A heart rhythm problem (such as QT prolongation)
A history of stroke
This medicine may cause the following problems:
Serotonin syndrome (may be life-threatening when used with certain other medicines)
Higher risk of bleeding
Vision problems
Seizures
Manic or hypomanic episodes
Low sodium levels in the blood
Heart rhythm changes
Changes in appetite or weight
Severe allergic reactions
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use before taking fluoxetine.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
If you are using an MAO inhibitor (MAOI), do not start taking fluoxetine until you’ve stopped taking the MAO inhibitor for at least 14 days. Do not start an MAOI until you’ve stopped taking fluoxetine for 5 weeks.
Fluoxetine should never be taken with the antipsychotic medications pimozide or thioridazine.
Some medicines and foods can affect how fluoxetine works or increase the risk or severity of side effects. Alternatively, fluoxetine can change the effectiveness and safety of other drugs. Tell your doctor if you are taking:
Other antidepressants
Drugs that treat mental health conditions such as anxiety, mood problems, or psychosis
Amphetamines
Blood thinners
Drugs that treat heart rhythm problems
Drugs that make you pee (diuretics)
Migraine treatments called triptans
Phenothiazine drugs
NSAIDs such as aspirin or ibuprofen
The narcotic painkillers tramadol, fentanyl, methadone, or levomethadyl
The anti-seizure drugs carbamazepine or phenytoin
The antibiotics erythromycin, moxifloxacin, gatifloxacin, or sparfloxacin
The malaria drugs mefloquine or halofantrine
Dolasetron, tacrolimus, probucol, or pentamidine
The supplements St. John’s wort or tryptophan
Do not drink alcohol while you are using this medicine.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, muscle relaxants, and alcohol.
Find more detailed information about fluoxetine interactions to avoid here.
Serious side effects
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect including:
Unusual behavior, thoughts of hurting yourself or others, feeling more excited or energetic than usual, trouble sleeping
Eye pain, sudden vision changes, seeing halos around lights
Unusual bleeding or bruising
Confusion, weakness, muscle twitching
Feeling more excited or energetic than usual, racing thoughts, euphoric mood
Seizures
Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, rigid muscles, seeing or hearing things that are not there
Blistering, peeling, red skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less serious side effects
Trouble sleeping
Nausea
Headache
Weakness
Diarrhea
Loss of appetite
Drowsiness
Anxiety
Tremor
Dry mouth
Yawning
Sexual problems
Find more detailed information about fluoxetine side effects here.
Fluoxetine hydrochloride capsule prescribing information, DailyMed (NIH National Library of Medicine)
Fluoxetine hydrochloride delayed-release capsule prescribing information, DailyMed (NIH National Library of Medicine)
Fluoxetine hydrochloride liquid prescribing information, DailyMed (NIH National Library of Medicine)
Fluoxetine hydrochloride tablet prescribing information, DailyMed (NIH National Library of Medicine)
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