Aldactone, CaroSpir
Spironolactone
Tablet, oral suspension (liquid)
Diuretic, potassium-sparing diuretic, cardiovascular agent, aldosterone antagonist, mineralcorticoid
Tablet, oral suspension (liquid)
By mouth
Spironolactone is used with other drugs to treat high blood pressure and heart failure. Healthcare providers also use spironolactone as a backup drug for fluid buildup due to liver cirrhosis, kidney disease, or other causes. Common off-label uses include difficult-to-treat acne and unwanted body hair (hirsutism), but neither of these uses is approved by the FDA.
Tablet
25 mg
50 mg
100 mg
Oral suspension (liquid)
25 mg/5 mL
For heart failure in adults: 25–50 mg taken by mouth once per day
For hypertension in adults: 25–100 mg taken by mouth divided into 1–2 doses per day
For edema in adults: 25–200 mg taken by mouth daily in single or divided doses
For primary hyperaldosteronism in adults: 100–400 mg taken by mouth once per day in preparation for surgery OR lowest effective daily maintenance dose for patients unsuitable for surgery
Spironolactone
30 tablets disp pack
Spironolactone
100mg tablet
Spironolactone
25mg tablet
Spironolactone
50mg tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
This medicine may be taken with or without food, but it should be taken the same way (with or without food) each day.
How to take spironolactone tablets
Swallow the tablet whole. Do not crush it or try to mix it with food or liquid.
How to take spironolactone oral suspension
Shake the bottle well before measuring out a dose.
Measure the oral liquid medicine with a calibrated oral syringe or similar measuring device.
Oral suspension doses are different from tablet doses. Do not switch from one to another without getting a doctor’s prescription.
Store spironolactone tablets or oral suspension at room temperature.
Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose.
Do not take extra medicine to make up for a missed dose
This medicine is not right for everyone.
Do not use spironolactone if:
You have had an allergic reaction to spironolactone
You have Addison’s disease.
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
Your doctor will do lab tests regularly to check on the effects of this medicine. Keep all appointments.
Tell your doctor if you are pregnant or breastfeeding.
Tell your doctor if you have:
Kidney disease
Liver disease
Urinary retention (trouble urinating)
Diabetes
This medicine may cause the following problems:
Low blood pressure
Worsening of kidney function
Electrolyte imbalance
Elevated blood sugar levels
Alkalosis
Elevated uric acid levels
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
You should not use the liquid version of spironolactone for doses over 100 mg. Ask the doctor to switch you to tablets.
Do not stop using the medicine without talking to the doctor.
Keep this medication out of the reach of children.
To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use before taking spironolactone.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Do not use this medicine together with another diuretic called eplerenone.
Some medicines may cause problems when combined with spironolactone. Tell your doctor if you are also taking:
Blood pressure medications, particularly ACE inhibitors or angiotensin II receptor blockers (ARBs)
Corticosteroids such as prednisone
NSAIDs such as aspirin or ibuprofen
The heart failure drug digoxin
The antibiotic trimethoprim
The cholesterol drug cholestyramine
Lithium
Avoid potassium supplements, potassium salt substitutes, or medicines containing supplements. The doctor may also ask you to avoid foods high in potassium. Combining these with spironolactone could cause high potassium levels in the body.
Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.
Find more detailed information about spironolactone drug interactions here.
Serious side effects
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect including:
Dry mouth, increased thirst, muscle cramps, uneven heartbeat, confusion, weakness, or numbness, or tingling in your hands, feet, or lips
Confusion, weakness, muscle twitching
Heart palpitations, chest pain, uneven heartbeat, muscle weakness, numbness in the arms or legs
Decreased urination, swelling in the legs, ankles, or feet, fatigue, confusion, irregular heartbeat, chest pain
Blood in your stools or dark stools, vomiting blood or material that looks like coffee grounds, abdominal pain
Yellow skin or eyes
Unusual bleeding, bruising, or weakness
Lightheadedness, dizziness, drowsiness, fainting
Blistering, peeling, red skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less serious side effects
Fatigue
Electrolyte imbalance
Dehydration
Nausea and vomiting
Abdominal pain or cramps
Muscle cramps
Breast development in men
Find more detailed information about spironolactone side effects here.
Aldactone spironolactone tablet prescribing information, DailyMed (NIH National Library of Medicine)
CaroSpir spironolactone oral suspension prescribing information, DailyMed (NIH National Library of Medicine)
Hyperaldosteronism, StatPearls
Spironolactone, StatPearls
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