What is Propranolol Hcl: Uses, Warnings & Interactions

Updated Mar 27, 2024  •  Published Dec 30, 2020

Propranolol Hcl overview

BRAND NAMES:

  • Inderal LA, Inderal XL, InnoPran XL, Hemangeol

Generic Names:

  • Propranolol HCl

Uses:

  • Treats high blood pressure, angina (chest pain), abnormal heart rhythms (atrial fibrillation or supraventricular tachycardia), and enlarged heart (idiopathic hypertrophic subaortic stenosis). It also helps prevent heart attack, stroke, and similar problems in the weeks and months following a heart attack. Other uses include migraine headache prevention, essential tremor, and proliferating infantile hemangioma.

Therapeutic Classes:

  • Beta blocker, antianginal, antiarrhythmic, antihypertensive, antimigraine, cardiovascular agent

Forms:

  • Tablet, oral solution (liquid), injection

How it’s taken:

  • By mouth

What is Propranolol Hcl used for?

Propranolol is used to treat a variety of cardiovascular problems, including high blood pressure, chest pain (angina), heart rhythm problems, heart attack, and an enlarged heart. The FDA has also approved it as a way to prevent migraine headaches, reduce tremors, or control some of the effects of adrenal gland cancer. In infants, propranolol is FDA-approved to treat overgrown blood vessels just beneath a baby’s skin, a condition called infantile hemangioma. In addition to all these uses, healthcare providers frequently prescribe it off-label for a variety of unapproved uses, including performance anxiety, dangerously high levels of thyroid hormones, restless leg syndrome, and other conditions.

What form(s) does Propranolol Hcl come in

  • Tablet

    • 10 mg

    • 20 mg

    • 40 mg

    • 60 mg

    • 80 mg

  • Oral solution (liquid)

    • 4.28 mg/mL

    • 20 mg/5 mL

    • 40 mg/5 mL

  • Injection

    • 1 mg/mL

What are common Propranolol Hcl doses?

  • For hypertension in adults: 80–240 mg daily mg divided into 2–3 doses 

  • For chest pain in adults: 80–320 mg daily in divided doses

  • For heart rhythm problems in adults: 10–30 mg three or four times daily OR 1–3 mg intravenous injections in a hospital

  • To prevent cardiovascular events after a heart attack in adults: 180–240 mg daily given in divided doses 

  • For enlarged heart in adults: 20–40 mg three or four times daily

  • For migraine prophylaxis in adults: 160–240 mg daily given once (sustained-release) or in divided doses (immediate-release)

  • For essential tremor: 120 mg daily given in divided doses

  • For adrenal gland cancer (pheochromocytoma) in adults: 60 mg daily in divided doses (before surgery) or 30 mg daily in divided doses (for inoperable tumors)

  • For progressing infantile hemangiomas: 0.4 mg/kg twice daily for 6 months

  • Find more detailed information about propranolol dosage, strengths, and forms here.

Common Propranolol Hcl prescriptions

  • Propranolol HCl
    500ml of 20mg/5ml bottle

  • Propranolol HCl
    500ml of 40mg/5ml bottle

  • Propranolol HCl
    5ml of 20mg/5ml cup

  • Propranolol HCl
    10mg tablet

  • Propranolol HCl
    20mg tablet

  • Propranolol HCl
    40mg tablet

  • Propranolol HCl
    60mg tablet

  • Propranolol HCl
    80mg tablet

  • Propranolol HCl
    1ml of 1mg/ml vial

How to take Propranolol Hcl

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine may come with a medication guide. Ask your pharmacist for a copy if you do not have one.

  • How to take propranolol tablets

    • Take propranolol tablets with food.

    • Swallow the propranolol tablet whole.

    • Store propranolol tablets at room temperature and protect them from light.

  • How to take propranolol capsules

    • Take propranolol capsules at bedtime.

    • Propranolol capsules can be taken with or without food but must be taken the same way each time. 

    • Swallow the capsule whole with a glass of water. Do not chew, break, or open the capsule.

    • Store propranolol capsules at room temperature, protected from light, moisture, freezing, and excessive heat.

  • How to take propranolol oral solution

    • Take the oral solution with food.

    • There is no need to shake the bottle before measuring a dose. 

    • Measure doses with the calibrated oral syringe that comes with this medicine.

    • Store propranolol oral solution at room temperature, protected from freezing or excessive heat.

  • How to give Hemangeol to a baby

    • Give the baby two doses a day spaced at least 9 hours apart.

    • Always give the baby a Hemangeol dose while feeding or immediately after feeding.

    • Do not give the baby Hemangeol if it’s vomiting, not eating, or has signs of low blood sugar.

    • There is no need to shake the bottle before measuring a dose. 

    • Insert the oral syringe into the baby’s mouth against the inside of a cheek and slowly squirt it into its mouth.

    • You can also mix the dose with milk or juice in the baby’s bottle.

    • Keep the baby upright for a few minutes after it’s swallowed the dose.

    • If the baby spits out or vomits up the dose, do not give it another dose until the next scheduled dose.

    • Store Hemangeol at room temperature. Do not freeze it.

    • Throw away the open bottle after 2 months, even if there’s some medicine left over.

What to do if you miss a dose of Propranolol Hcl

  • For propranolol tablets or oral solution, take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. 

  • For propranolol capsules, ask the doctor what to do if a dose is missed.

  • If a dose of Hemangeol is missed, skip the missed dose. Just give the next dose at its regularly scheduled time.

  • Do not take extra medicine to make up for a missed dose.

Propranolol Hcl contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have:

    • Lung diseases such as COPD or asthma 

    • Certain types of heart problems (heart block, sinus bradycardia, cardiogenic shock)

    • Had an allergic reaction to propranolol 

  • Hemangeol should not be given to:

    • Infants who are vomiting or not eating

    • Premature babies younger than 5 weeks of age

    • Babies weighing less than 2 kilograms

    • Infants with a slow heart rate (less than 80 beats per minute)

    • Infants with low blood pressure

    • Infants with asthma

    • Infants with adrenal gland cancer

    • Infants who have had an allergic reaction to propranolol

Propranolol Hcl warnings

  • Tell any doctor or other healthcare provider who treats you that you are using this medicine.

  • Your doctor may need to do lab tests regularly to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding.

  • Tell your doctor if you have:

    • Kidney disease

    • Liver disease

    • Breathing problems such as bronchitis, asthma, or emphysema

    • Angina (chest pain)

    • Heart failure

    • Diabetes

    • Overactive thyroid

    • Adrenal gland cancer

    • Congenital heart problems

    • A history of severe allergic reactions

  • This medicine may cause the following problems: 

    • Worsening of angina

    • Worsening of heart failure

    • Slow heart rate

    • Breathing problems

    • Stroke (in children with severe blood vessel problems in the brain)

  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Propranolol Hcl interactions

  • To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use before taking amitriptyline.

  • Tell other healthcare providers you are using this medicine before they prescribe new medications.

  • Some medicines and foods can affect how propranolol works or increase the risk or severity of side effects. Tell your doctor if you are taking:

    • Blood pressure medications

    • Drugs that treat heart rhythm abnormalities

    • NSAIDs such as aspirin or ibuprofen

    • Drugs that treat high cholesterol

    • Steroids such as prednisone

    • Migraine treatments called triptans

    • Drugs that treat depression

    • MAO inhibitors (MAOIs)

    • Epinephrine, a rescue medicine for severe allergic reactions or asthma attacks

    • The asthma or COPD treatment theophylline

    • The anti-seizure drugs phenytoin or carbamazepine

    • The blood thinner warfarin

    • The over-the-counter heartburn drug cimetidine

  • Do not drink alcohol when taking propranolol.

Find more detailed information about propranolol interactions to avoid here.

Propranolol Hcl side effects

Serious side effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Slow, fast, or uneven heartbeat

  • Chest pain or worsening chest pain

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness

  • Lightheadedness, dizziness, or fainting

  • Trouble breathing or wheezing

  • Blistering, peeling, or red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less serious side effects

  • Dizziness

  • Lightheadedness

  • Tiredness 

  • Nausea

Find more detailed information about propranolol side effects here.

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