What is Glyburide-Metformin: Uses, Warnings & Interactions

Updated Jan. 12, 2021  •  Published Dec. 30, 2020

Glyburide-Metformin overview

BRAND NAMES:

  • Glucovance

Generic Names:

  • Glyburide-Metformin

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic, Biguanide/Sulfonylurea Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Glyburide-Metformin used for?

Glyburide-Metformin used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It work by helping to restore your body's proper response to the insulin you naturally produce.

What form(s) does Glyburide-Metformin come in

  • Tablet

What are common Glyburide-Metformin doses?

  • Tablet 2.5-500MG

  • Tablet 1.25-250MG

  • Tablet 5-500MG

Common Glyburide-Metformin prescriptions

  • glyBURIDE-metFORMIN
    1.25-250mg tablet

  • glyBURIDE-metFORMIN
    2.5-500mg tablet

  • glyBURIDE-metFORMIN
    5-500mg tablet

How to take Glyburide-Metformin

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Glyburide-Metformin contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to glyburide or metformin.

Glyburide-Metformin warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, congestive heart failure, adrenal or pituitary gland problems, G6PD deficiency, vitamin B12 deficiency, or history of alcohol abuse.

  • This medicine may cause the following problems:Lactic acidosisHigher risk of heart or blood vessel problemsLow blood sugar levels

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using it before you have surgery, an X-ray, a CT scan, or other medical tests.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Unusual tiredness or weakness

Glyburide-Metformin interactions

  • Do not use this medicine together with bosentan.

  • Some medicines can affect how this medicine works. Tell your doctor about all other medicines that you are using, including acetazolamide, chloramphenicol, cimetidine, ciprofloxacin, cyclosporine, dichlorphenamide, disopyramide, dolutegravir, fluoxetine, isoniazid, miconazole, niacin, phenytoin, probenecid, ranolazine, topiramate, vandetanib, or zonisamide.

  • If you are also taking colesevelam, take it at least 4 hours after you take this medicine.

  • Do not drink alcohol while you are using this medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Glyburide-Metformin side effects

Serious Side Effects

  • Trouble breathing, lightheadedness, dizziness

  • Blurred vision, changes in vision

  • Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion

  • Unusual tiredness or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger

Less Serious Side Effects

  • Mild nausea, diarrhea, or stomach upset