What is Pioglitazone Hcl-Glimepiride: Uses, Warnings & Interactions

Updated Jan. 13, 2021  •  Published Dec. 30, 2020

Pioglitazone Hcl-Glimepiride overview

BRAND NAMES:

  • Pioglitazone HCl/Glimepiride, Duetact

Generic Names:

  • Pioglitazone Hcl-Glimepiride

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Pioglitazone Hcl-Glimepiride used for?

Duetact is indicated for the treatment of diabetes type 2. It contains glimepiride and pioglitazone and work to lower the levels of glucose in the blood. It is commonly prescribed together with diet and exercise to help improve blood glucose levels in patients with this condition. Duetact is indicated for use in adults and is available as a tablet.

What form(s) does Pioglitazone Hcl-Glimepiride come in

  • Tablet

What are common Pioglitazone Hcl-Glimepiride doses?

  • Tablet 30-4MG

  • Tablet 30-2MG

Common Pioglitazone Hcl-Glimepiride prescriptions

  • Pioglitazone HCl-Glimepiride
    30-2mg tablet

  • Pioglitazone HCl-Glimepiride
    30-4mg tablet

How to take Pioglitazone Hcl-Glimepiride

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk. Take this medicine with the first meal of the day.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule, unless your doctor tells you otherwise. Do not double doses.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule, unless your doctor tells you otherwise. Do not double doses.

  • Oral routeIt is best to take this medicine with food or milk. Take this medicine with the first meal of the day.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Pioglitazone Hcl-Glimepiride contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to glimepiride, pioglitazone, or a sulfa drug.

Pioglitazone Hcl-Glimepiride warnings

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

  • Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, adrenal or pituitary gland problems, G6PD deficiency, macular edema (swelling of the back of the eye), or a history of alcohol abuse or bladder cancer. Also tell your doctor if you drink alcohol.

  • This medicine may cause the following problems:Increased risk of heart or blood vessel problemsLow blood sugar levelsLiver problemsIncreased risk for bladder cancer if you use this medicine for a long timeIncreased risk for broken bones

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

Pioglitazone Hcl-Glimepiride interactions

  • Some medicines can affect how this medicine works. Tell your doctor about all other medicines that you are using, including the following:Clonidine, fluconazole, gemfibrozil, miconazole, reserpine, rifampin, topiramateBeta-blocker medicineInsulin or other oral diabetes medicine.

  • If you also take colesevelam, take this medicine at least 4 hours before you take colesevelam.

  • Women: This medicine may cause you to ovulate if you have not gone through menopause yet. This could happen even if you have a history of irregular periods or problems ovulating. Talk to your doctor about effective birth control.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Pioglitazone Hcl-Glimepiride side effects

Serious Side Effects

  • Change in how much or how often you urinate, painful urination, lower back or side pain, blood in your urine

  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Blurred vision or changes in vision

  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing

Less Serious Side Effects

  • Cough, runny or stuffy nose, sore throat

  • Diarrhea, mild nausea, or vomiting

  • Headache