What is Gabapentin: Uses, Warnings & Interactions

Updated Feb 1, 2024  •  Published Dec 30, 2020

Gabapentin overview

BRAND NAMES:

  • Neurontin, Gralise

Generic Names:

  • Gabapentin

Uses:

  • Treats seizures and pain caused by shingles

Therapeutic Classes:

  • Anticonvulsant, neuropathic pain agent

Forms:

  • Capsule, tablet, oral solution

How it’s taken:

  • By mouth

What is Gabapentin used for?

  • Gabapentin is FDA-approved to prevent seizures and relieve nerve pain following a shingles infection.

  • Gabapentin is commonly used off-label to treat nerve pain, fibromyalgia, tremor, alcohol dependence, and some of the symptoms of menopause.

What form(s) does Gabapentin come in

  • Capsule

    • 100 mg

    • 300 mg

    • 400 mg

  • Tablet

    • 600 mg

    • 800 mg

  • Oral solution (liquid)

    • 250 mg/5 mL

What are common Gabapentin doses?

  • For partial seizures in adults and children 12 years or older: 300–600 mg taken three times daily

    • For children 5–11 years old: 25-35 mg/kg (11.4-15.9 mg/lb) per day divided into three daily doses

    • For children 3–4 years old: 25-35 mg/kg (18.2 mg/lb) per day divided into three daily doses

  • For postherpetic neuralgia in adults: 300–600 mg taken three times daily

RELATED: Gabapentin dosage, forms, and strengths

Common Gabapentin prescriptions

  • Gabapentin
    100 capsules bottle

  • Gabapentin
    470ml of 250mg/5ml bottle

  • Gabapentin
    473ml of 250mg/5ml bottle

  • Gabapentin
    100mg capsule

  • Gabapentin
    300mg capsule

  • Gabapentin
    400mg capsule

  • Gabapentin
    5ml of 250mg/5ml cup

  • Gabapentin
    600mg tablet

  • Gabapentin
    800mg tablet

How to take Gabapentin

  • Take your medicine as directed. The dose may change until the most effective dose amount is reached. 

  • If you have epilepsy, do not allow more than 12 hours to pass between doses.

  • Gabapentin can be taken with or without food.

  • How to take gabapentin tablets

    • Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

    • If you break a tablet into two pieces, use the second half as your next dose. Discard any unused half-tablet after 28 days.

  • How to take gabapentin capsules

    • Swallow the capsule whole with a glass of water. Do not open, crush, or chew it.

    • If it’s too difficult to swallow the capsule, the patient or a caregiver can carefully open it, sprinkle the contents into a small cup of water, juice, or apple sauce, and give the dose that way.

  • How to take gabapentin oral solution 

    • Shake the closed bottle well before each use.

    • Measure the oral liquid with a syringe or medicine cup with millimeter markings. Gabapentin oral suspension usually comes with a 12 ml dosing syringe. 

    • Remove the child-proof cap from the bottle. 

    • Make sure the syringe adapter has been pushed into the bottle opening. If not, fully insert the syringe adapter into the bottle opening.

    • Push the syringe plunger all the way down to the tip.

    • Insert the syringe tip into the adapter.

    • Turn the bottle and syringe upside down.

    • Slowly draw out enough liquid to the correct milliliter mark.

    • Turn the bottle back to the upright position.

    • Remove the syringe and place the tip in the mouth.

    • Slowly empty the contents into the mouth and swallow.

    • Securely fasten the child-safety cap back on the bottle.

What to do if you miss a dose of Gabapentin

  • If you miss a dose of gabapentin, take the missed dose as soon as you remember. Take the next dose at its scheduled time. If it is almost time for the next dose, skip the missed dose and take the next dose at its scheduled time. Do not take extra medicine to make up for a missed dose. 

  • If you are taking gabapentin for seizures, ask your doctor or pharmacist for directions on how to handle a missed dose.

Gabapentin contraindications

  • This medicine is not right for everyone. 

  • Do not take gabapentin if you have had an allergic reaction to gabapentin.

Gabapentin warnings

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Before taking this drug, tell the prescribing doctor about:

    • Any history of depression, mood problems, or suicidal thoughts

    • Kidney problems or hemodialysis

    • Lung or breathing problems

    • Diabetes

    • Pregnancy

    • Breastfeeding

  • This medicine can cause serious problems such as:

    • Suicidal thoughts and behaviors

    • Worsening of depression

    • Accidents or injuries due to sleepiness or dizziness

    • Neuropsychiatric symptoms in children

    • Severe or life-threatening allergic reactions

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Gabapentin interactions

  • Some medicines can affect how gabapentin works. Tell the prescribing healthcare provider about all prescription drugs, over-the-counter medicines, and supplements you are using.

  • Gabapentin should never be combined with the antidepressant bupropion or the GERD medication metoclopramide.

  • Because gabapentin slows down the central nervous system and breathing, it should be used with caution with opioids.

  • Tell your doctor if you use anything else that makes you sleepy such as benzodiazepines, antihistamines, or sleeping pills.

  • Do not drink alcohol while you are using this medicine.

Gabapentin side effects

Serious side effects

Gabapentin can cause serious side effects. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect including:

  • Unusual moods or behaviors, thoughts of hurting yourself, feeling depressed

  • Blue lips, fingernails, or skin, chest pain, fast heartbeat, trouble breathing

  • Behavior problems, agitation, aggression, restlessness, trouble concentrating, moodiness (especially in children)

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Problems with coordination, shakiness, unsteadiness, unusual eye movement

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Severe skin reaction: blistering, peeling, red skin rash

  • DRESS syndrome: Fever, skin rash, swollen neck glands, change in how much or how often you urinate, or bloody or cloudy urine

Less serious side effects include:

  • Dizziness

  • Sleepiness

  • Swelling in your hands, ankles, or feet

  • Weakness or lack of energy

  • Diarrhea