What is Fluorouracil: Uses, Warnings & Interactions

Updated Jan 12, 2021  •  Published Dec 30, 2020

Fluorouracil overview

BRAND NAMES:

  • Carac, Efudex, Fluoroplex, Tolak

Generic Names:

  • Fluorouracil

Uses:

  • Treats actinic or solar keratoses (rough, raised areas of skin heavily exposed to sun). Also treats basal cell carcinoma (skin cancer).

Therapeutic Classes:

  • Antineoplastic, Dermatological, Antineoplastic Agent

Forms:

  • Cream, Liquid

How it’s taken:

  • On the skin

What form(s) does Fluorouracil come in

  • Cream

  • Liquid

What are common Fluorouracil doses?

  • Tube 30GM of 0.5%

  • Tube 40GM of 5%

  • Bottle 1GM of

  • Bottle 100GM of

  • Bottle 10ML of 2%

  • Bottle 10ML of 5%

  • Vial 20ML of 1GM/20ML

  • Vial 50ML of 2.5GM/50ML

  • Vial 100ML of 5GM/100ML

  • Vial 10ML of 500MG/10ML

Common Fluorouracil prescriptions

  • Fluorouracil
    10ml of 2% bottle

  • Fluorouracil
    10ml of 5% bottle

  • Fluorouracil
    30gm of 0.5% tube

  • Fluorouracil
    40gm of 5% tube

  • Fluorouracil
    30gm of 0.5% tube of cream

  • Fluorouracil
    40gm of 5% tube of cream

  • Fluorouracil
    100ml of 5gm/100ml vial

  • Fluorouracil
    10ml of 500mg/10ml vial

  • Fluorouracil
    20ml of 1gm/20ml vial

  • Fluorouracil
    50ml of 2.5gm/50ml vial

How to take Fluorouracil

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Topical application routeUse this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Wash the skin to be treated with soap and water and wait 10 minutes before applying the medicine.

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.

  • You may use a glove, nonmetal applicator, or your fingers to apply this medicine.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • If your doctor tells you to use a bandage, use a gauze bandage with tape. A plastic bandage is more likely to cause skin irritation.

  • Wash the skin to be treated with soap and water and wait 10 minutes before applying the medicine.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • If your doctor tells you to use a bandage, use a gauze bandage with tape. A plastic bandage is more likely to cause skin irritation.

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.

  • Topical application routeUse this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • You may use a glove, nonmetal applicator, or your fingers to apply this medicine.

What to do if you miss a dose of Fluorouracil

  • Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Fluorouracil contraindications

  • You should not use this medicine if you have had an allergic reaction to fluorouracil. Do not use this medicine if you are or may become pregnant. Do not use this medicine if you have dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

Fluorouracil warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Make sure your doctor knows if you are breast feeding. Tell your doctor if you are sensitive to preservatives, or if you have any other medical conditions.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Stomach pain, or diarrhea that contains blood.

Fluorouracil interactions

  • Topical application routeDo not put cosmetics or skin care products on the treated skin.

  • Make sure your doctor knows if you are breast feeding. Tell your doctor if you are sensitive to preservatives, or if you have any other medical conditions.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

Fluorouracil side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fever, chills, or vomiting.

  • Severe skin rash or itching.

  • Stomach pain, or diarrhea that contains blood.

  • Pain where the medicine is put on.

  • Swelling, blistering, redness, or peeling of skin.

Less Serious Side Effects

  • Pain where the medicine is put on.

  • Eye burning, itching, stinging, or watering.

  • Swelling, blistering, redness, or peeling of skin.

  • Hair loss.

  • Change in skin color where medicine is put on.

  • Mild skin itching or burning.