What is Colchicine-Probenecid: Uses, Warnings & Interactions

Updated Jan 12, 2021  •  Published Dec 30, 2020

Colchicine-Probenecid overview

Generic Names:

  • Colchicine-Probenecid

Uses:

  • Treats gout and gouty arthritis.

Therapeutic Classes:

  • Antigout

Forms:

  • Tablet

How it’s taken:

  • By mouth

What form(s) does Colchicine-Probenecid come in

  • Tablet

What are common Colchicine-Probenecid doses?

  • Tablet 0.5-500MG

Common Colchicine-Probenecid prescriptions

  • Colchicine-Probenecid
    0.5-500mg tablet

How to take Colchicine-Probenecid

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Drink 10 to 12 full glasses of liquids each day unless your doctor tells you differently. This will help to prevent kidney stones.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Drink 10 to 12 full glasses of liquids each day unless your doctor tells you differently. This will help to prevent kidney stones.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Colchicine-Probenecid contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to probenecid or colchicine, or if you are pregnant.

Colchicine-Probenecid warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney stones, a blood disorder, kidney disease, liver disease, or a history of stomach ulcers.

  • This medicine may cause the following problems:Increased gout symptoms, when you first start treatmentKidney stones

  • Tell any doctor or dentist who treats you that you are using this medicine, especially if you are going to have general anesthesia.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Colchicine-Probenecid interactions

  • Some foods and medicines can affect how probenecid works. Tell your doctor if you also use any of the following:MethotrexateSalicylate medicine, such as aspirin, topical medicine to treat pain, acne medicine, or medicine to treat diarrhea, nausea, and vomitingPenicillin, a sulfa drug, or a similar antibioticOral medicine for diabetesSulindacAcetaminophen, indomethacin, naproxen, ketoprofen, meclofenamateLorazepamRifampin

  • Tell your doctor if you are breastfeeding, or if you have kidney stones, a blood disorder, kidney disease, liver disease, or a history of stomach ulcers.

  • This medicine may cause the following problems:Increased gout symptoms, when you first start treatmentKidney stones

  • Tell any doctor or dentist who treats you that you are using this medicine, especially if you are going to have general anesthesia.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Colchicine-Probenecid side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blood in the urine, pain when urinating, back pain

  • Numbness or tingling in your hands or feet

  • Severe stomach pain, vomiting, or diarrhea

Less Serious Side Effects

  • Headache

  • Dizziness