What is Chloroquine Phosphate: Uses, Warnings & Interactions

Updated Jan 12, 2021  •  Published Dec 30, 2020

Chloroquine Phosphate overview

BRAND NAMES:

  • Aralen Phosphate

Generic Names:

  • Chloroquine Phosphate

Uses:

  • Prevents and treats malaria. Also treats extraintestinal amebiasis (liver infection). Also treats coronavirus (COVID-19) in certain hospitalized patients.

Therapeutic Classes:

  • Amebicide, Extraintestinal, Antimalarial, Antirheumatic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What form(s) does Chloroquine Phosphate come in

  • Tablet

What are common Chloroquine Phosphate doses?

  • Tablet 250MG

  • Tablet 500MG

  • Bottle 25GM of

Common Chloroquine Phosphate prescriptions

  • Chloroquine Phosphate
    250mg tablet

  • Chloroquine Phosphate
    500mg tablet

How to take Chloroquine Phosphate

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. If you take this medicine only once a week, always take it on the same day of each week.

  • Malaria prevention while traveling: You may need to start using this medicine 2 weeks before you start your trip. You may also need to keep using this medicine for 8 weeks after you get home. Ask your doctor about your schedule.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Missed dose: If you take your medicine once every 7 days, take the missed dose as soon as you can, then wait 7 days before taking another dose.If you take your medicine every day, take the missed dose as soon as you can. If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Malaria prevention while traveling: You may need to start using this medicine 2 weeks before you start your trip. You may also need to keep using this medicine for 8 weeks after you get home. Ask your doctor about your schedule.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. If you take this medicine only once a week, always take it on the same day of each week.

  • Missed dose: If you take your medicine once every 7 days, take the missed dose as soon as you can, then wait 7 days before taking another dose.If you take your medicine every day, take the missed dose as soon as you can. If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Chloroquine Phosphate contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to chloroquine or similar medicines. This medicine may increase your risk of heart rhythm problems (including QT prolongation, ventricular fibrillation, ventricular tachycardia). Chloroquine should only be used for COVID-19 in a hospital or during clinical trials. Do not take any medicine that contains chloroquine unless prescribed by your doctor.

Chloroquine Phosphate warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, blood disorders (including porphyria, G6PD deficiency), psoriasis, hearing problems, or a history of epilepsy or heart rhythm problems. Tell your doctor if you drink alcohol.

  • Tell your doctor if you have had eye or vision problems caused by chloroquine or similar drugs.

  • This medicine may cause the following problems:Heart problemsLow blood sugar, which could be life-threateningChanges in heart rhythm, including QT prolongationChanges in vision, eye damageMuscle and nerve problemIncreased risk of seizures

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Chloroquine Phosphate interactions

  • Some medicines can affect how chloroquine works. Tell your doctor if you are using any of the following:Azithromycin, cimetidine, cyclosporine, mefloquine, praziquantel, tamoxifenInsulin or other diabetes medicineMedicine to treat heart rhythm problems

  • Tell your doctor if you need a rabies vaccine.

  • Take antacids or kaolin at least 4 hours before or after taking this medicine.

  • Take ampicillin at least 2 hours before or after taking this medicine.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your may need to have your eyes, ears, and reflexes tested.

  • Children are very sensitive to this medicine. Accidental overdoses have occurred with small amounts of chloroquine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Chloroquine Phosphate side effects

Serious Side Effects

  • Changes in vision, trouble seeing, light flashes

  • Lightheadedness, dizziness, fainting

  • Swelling in your hands, ankles, or feet

  • Twitching or muscle movements you cannot control, problems with balance or walking, muscle weakness

  • Fast, pounding, or uneven heartbeat

  • Increased hunger, headache, confusion, shaking, trembling, sweating

  • Unusual bleeding, bruising, or weakness

  • Trouble breathing, cold sweat, bluish-colored skin

  • Trouble hearing, ringing in the ears

  • Seizures

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing