What is Carbidopa-Levodopa: Uses, Warnings & Interactions

Updated Jan 12, 2021  •  Published Dec 30, 2020

Carbidopa-Levodopa overview

BRAND NAMES:

  • Sinemet 25-250, Sinemet CR, Sinemet 25-100, Sinemet 10-100, Rytary

Generic Names:

  • Carbidopa-Levodopa

Uses:

  • Treats symptoms of Parkinson disease.

Therapeutic Classes:

  • Antiparkinsonian

Forms:

  • Dissolving Tablet, Tablet, Long Acting Capsule, Long Acting Tablet

How it’s taken:

  • By mouth

What form(s) does Carbidopa-Levodopa come in

  • Dissolving Tablet

  • Tablet

  • Long Acting Capsule

  • Long Acting Tablet

What are common Carbidopa-Levodopa doses?

  • Tablet 25-100MG

  • Tablet 25-250MG

  • Tablet 10-100MG

  • Tablet Disintegrating 25-100MG

  • Tablet Disintegrating 25-250MG

  • Tablet Disintegrating 10-100MG

Common Carbidopa-Levodopa prescriptions

  • Carbidopa-Levodopa
    10-100mg tablet

  • Carbidopa-Levodopa
    25-100mg tablet

  • Carbidopa-Levodopa
    25-250mg tablet

  • Carbidopa-Levodopa
    10-100mg tablet disintegrating

  • Carbidopa-Levodopa
    25-100mg tablet disintegrating

  • Carbidopa-Levodopa
    25-250mg tablet disintegrating

How to take Carbidopa-Levodopa

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine will take longer to work if you take it with a high-fat or high-protein meal. Ask your doctor or pharmacist if you should take it 1 or 2 hours before a meal.

  • Disintegrating tablet: Make sure your hands are dry before you handle the tablet. Do not remove the tablet from the bottle until you are ready to take it. Place the tablet on top of your tongue, where it will melt quickly.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeIf you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.

  • Extended-release capsule or sustained-release tablet: Swallow the capsule or tablet whole. Do not crush, break, or chew it.

  • Disintegrating tablet: Make sure your hands are dry before you handle the tablet. Do not remove the tablet from the bottle until you are ready to take it. Place the tablet on top of your tongue, where it will melt quickly.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Extended-release capsule or sustained-release tablet: Swallow the capsule or tablet whole. Do not crush, break, or chew it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeIf you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.

  • This medicine will take longer to work if you take it with a high-fat or high-protein meal. Ask your doctor or pharmacist if you should take it 1 or 2 hours before a meal.

Carbidopa-Levodopa contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to carbidopa or levodopa, or if you have narrow-angle glaucoma, skin lesions, or a history of skin cancer.

Carbidopa-Levodopa warnings

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine might cause your saliva, sweat, or urine to become dark red, brown, or black. This is nothing to worry about, but it could stain your clothes.

  • If you are already taking levodopa, stop taking it at least 12 hours before starting treatment with carbidopa/levodopa combination.

  • This medicine may make you dizzy or drowsy, or even cause you to fall asleep without warning. This could happen while you are driving, eating, or talking. Tell your doctor right away if this happens. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • This medicine may cause the following problems:Dyskinesia (trouble controlling movements)An increased risk for skin cancerUnusual changes in thoughts or behavior, such as the urge to gamble or an increased sex drive

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, endocrine problems, lung or breathing problems (such as asthma), a sleep disorder, heart or blood vessel problems, heart rhythm problems, or a history of heart attack. Tell your doctor if you have wide-angle glaucoma, phenylketonuria (PKU), or a history of stomach ulcer or mental illness.

Carbidopa-Levodopa interactions

  • This medicine might cause your saliva, sweat, or urine to become dark red, brown, or black. This is nothing to worry about, but it could stain your clothes.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell your doctor if you are using any mineral supplements or multivitamins with iron.

  • Do not use this medicine if you have used an MAO inhibitor (MAOI) within the past 14 days.

  • Some foods and medicines can affect how carbidopa/levodopa works. Tell your doctor if you are using any of the following:Isoniazid, metoclopramide, papaverine, phenytoin, reserpine, risperidone, tetrabenazineA phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine)Blood pressure medicineMedicine to treat depression or mental illness

Carbidopa-Levodopa side effects

Serious Side Effects

  • Unusual behavior, mood changes, seeing or hearing things that are not there, or thoughts of hurting yourself

  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)

  • Falling asleep in the middle of an activity

  • Compulsive behavior or intense urges you cannot control

  • Chest pain, trouble breathing, fast or uneven heartbeat

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Drowsiness or sleepiness

  • Nausea

  • Pink or red urine, dark sweat or saliva, or heavy sweating

  • Headache, trouble sleeping

  • Lightheadedness, dizziness, or fainting