Beta blockers are commonly prescribed medications to treat high blood pressure (hypertension) and heart problems, including irregular heart rhythm and heart failure. These drugs work by blocking beta receptors found on the heart and blood vessels, although they can also affect beta receptors found in the kidneys, lungs, and other parts of the body.
Cardioselective beta blockers work by binding to beta-1 receptors, which are abundant in the heart muscle. Compared to nonselective beta blockers, cardioselective beta blockers carry a lower risk of certain side effects, such as worsening lung function in those with COPD or other lung diseases.
Continue reading to learn more about cardioselective beta blockers, how they work, their side effects, and more.
Drug name | Learn more | See SingleCare price |
---|---|---|
Tenormin | tenormin details | tenormin price |
Atenolol | atenolol details | atenolol price |
Bisoprolol Fumarate | bisoprolol-fumarate details | bisoprolol-fumarate price |
Lopressor | lopressor details | lopressor price |
Metoprolol Tartrate | metoprolol-tartrate details | metoprolol-tartrate price |
Toprol Xl | toprol-xl details | toprol-xl price |
Metoprolol Succinate Er | metoprolol-succinate-er details | metoprolol-succinate-er price |
Bystolic | bystolic details | bystolic price |
Nebivolol HCl | nebivolol-hcl details | nebivolol-hcl price |
Esmolol Hcl | esmolol-hcl details | esmolol-hcl price |
Betaxolol Hcl | betaxolol-hcl details | betaxolol-hcl price |
Acebutolol Hcl | acebutolol-hcl details | acebutolol-hcl price |
Celiprolol
Practolol
Xamoterol
Beta blockers, or beta-adrenergic blocking agents, are medications that help decrease blood pressure and lower stress on the heart. There are two types of beta blockers: nonselective and cardioselective.
Nonselective beta blockers, also known as first-generation beta blockers, can bind to beta-1 and beta-2 receptors found in the heart, lungs, and blood vessels. Examples of nonselective beta blockers include carvedilol, nadolol, timolol, sotalol, labetalol, and pindolol. Propranolol is a nonselective beta blocker that was the first beta blocker to be widely used in medicine for angina, or chest pain.
Cardioselective beta blockers inhibit the binding of beta-1 receptors, mostly found in the heart. These medications help treat hypertension, arrhythmias, acute myocardial infarctions (heart attacks), and congestive heart failure. Examples of cardioselective beta blockers include atenolol, acebutolol, bisoprolol, esmolol, and metoprolol. These medications are sometimes combined with other blood pressure lowering medications, including vasodilators, ACE inhibitors, diuretics, alpha blockers, and calcium channel blockers.
Cardioselective beta blockers work by blocking beta-1 receptors, which prevents epinephrine from binding to these receptors. As a result, these medications block the effects of epinephrine, also known as adrenaline, in order to decrease heart rate and the contractility of the heart.
Epinephrine is a neurotransmitter and hormone that is naturally released from the adrenal glands to regulate blood pressure and heart functions. It is also involved with the fight-or-flight response, or an acute response that arises during stressful situations. During the fight-or-flight response, the body’s sympathetic nervous system produces a flood of adrenaline to prepare the body for an impending threat.
Normally, epinephrine binds to beta-1 adrenergic receptors in the heart, kidneys, lungs, and smooth muscles of the arterial blood vessels. Too much stimulation of beta-1 receptors on the heart muscles can lead to an increased heart rate and an irregular heart rhythm, as well as increased pressure on the heart. Stimulation of beta-1 receptors in the kidney also leads to the release of renin, an enzyme that can act to increase blood pressure. Beta blockers are antagonists that block the effects of epinephrine to slow heart rate and relieve pressure on the blood vessels.
Cardioselective beta blockers are often prescribed for a number of conditions affecting the heart and blood vessels. They have FDA-approved and off-label uses.
Chronic chest pain
Heart failure
Heart attacks
Left ventricular dysfunction after a heart attack
Irregular heart rhythm
Certain cardioselective beta blockers have intrinsic sympathomimetic activity (ISA). These beta blockers have actions that can increase vascular resistance, which leads to increased blood pressure. Beta blockers with ISA can also increase heart rate and have less of an effect on the reduction of cardiac output. Cardioselective beta blockers with ISA include celiprolol and acebutolol.
In some cases, cardioselective beta blockers without ISA may be preferred over cardioselective beta blockers with ISA. Beta blockers without ISA may have more beneficial effects on blood pressure and heart rate than other beta blockers. They may also have more of an effect on reducing cardiac output to decrease stress on the heart. Cardioselective beta blockers without ISA include bisoprolol, metoprolol, and atenolol.
Cardioselective beta blockers are commonly prescribed to adults with high blood pressure or heart disease. They are also used to manage chronic chest pain in people with coronary artery disease. The American College of Cardiology recommends a cardioselective beta blocker to help reduce the risk of death in those with heart failure or reduced left ventricular function. These medications are usually taken as daily tablets in both men and women, and they should only be used as prescribed by a healthcare provider.
The use of beta blockers in the elderly is usually safe and recommended for certain cardiovascular conditions. However, older patients may be more likely to have problems with kidney, liver, and heart function. Some evidence and guidelines suggest avoiding the use of a beta blocker to treat high blood pressure in older patients over the age of 60 unless they also have another condition like heart failure. If treatment is recommended, older adults are usually started on a lower dose of a beta blocker.
Certain beta blockers may be recommended for children, especially children with chronic heart failure. The exact dose and type of drug prescribed will depend on the child’s condition, age, and other factors.
Cardioselective beta blockers are generally safe medications to take. Compared to nonselective beta blockers, cardioselective beta blockers may have a lower risk of causing bronchospasms. Therefore, these drugs may be safer for people with lung diseases, such as chronic obstructive pulmonary disease or asthma.
No current recalls available.
Cardioselective beta blockers have specific contraindications. The use of cardioselective beta blockers should be avoided in people with a history of edema, or fluid retention, who are not already being treated with a diuretic. Cardioselective beta blockers should not be used in people with complete or second-degree heart block, which is a type of heart rhythm disorder. Beta blockers should also not be used in those with severe bradycardia (slow heart rate), cardiogenic shock, decompensated heart failure, or sick sinus syndrome. Beta blockers can slow the heart rate and worsen the effects of these problems.
Cardioselective beta blockers are not generally recommended for people with severe asthma or COPD. Although the risk is lower with cardioselective beta blockers than nonselective beta blockers, there is still a risk of an exacerbation, or acute worsening of respiratory symptoms. A healthcare provider should be consulted to determine whether a cardioselective beta blocker would be appropriate in someone with mild to moderate lung disease.
The dose of certain cardioselective beta blockers may need to be adjusted in those with liver or kidney disease.
Those who are allergic to any of the ingredients in beta blockers should avoid taking these medications.
Cardioselective beta blockers may interact with other medications including high blood pressure medications, heart rhythm medications, certain antidepressants, nitrates, antidiabetic drugs, NSAIDs, and drugs used for allergy and cold symptoms. Discuss with a doctor other medications you may be using, such as prescription medications, over-the-counter medicines, and herbal supplements before using a cardioselective beta blocker.
No, cardioselective beta blockers are not controlled substances.
The most common side effects of cardioselective beta blockers include:
Dizziness
Headache
Fatigue
Weakness
Dry mouth or eyes
Nausea
Vomiting
Stomach discomfort
Beta blockers may also cause other adverse effects such as slow heartbeat (bradycardia) and low blood pressure (hypotension). Less common side effects of cardioselective beta blockers include memory problems, confusion, and sexual dysfunction, including erectile dysfunction.
When blood sugar levels fall, a person with diabetes normally experiences a rapid heart rate (tachycardia), tremors, and irritability. Cardioselective beta blockers can mask certain signs of hypoglycemia in patients with diabetes, including tachycardia. Blood sugar levels may need to be monitored more closely in patients with diabetes. A person with diabetes should also take extra precautions, such as having sugar tablets or juice on hand, to treat hypoglycemia.
Allergic reactions are possible with cardioselective beta blockers. Seek immediate medical attention if you experience hives, rash, trouble breathing, or swelling of the face or throat while taking a cardioselective beta blocker.
Overdose with beta blockers is also possible. Signs of an overdose may include severe low blood pressure, cardiac arrest, heart failure, bronchospasm, nausea, vomiting, mental impairment, and coma.
This is not a complete list of side effects, and others may occur. Consult a healthcare provider for other possible side effects, drug interactions, warnings, and precautions before taking a cardioselective beta blocker.
Beta blockers are available in both brand and generic forms. They can be administered as an oral tablet or intravenous solution, although a healthcare provider will help determine the most appropriate formulation depending on the condition being treated.
Medicare and insurance plans usually cover beta blockers. However, the costs with or without insurance can vary depending on the drug, strength, and quantity prescribed. Savings options, such as the SingleCare discount card, are available for all types of patients at participating pharmacies. Savings cards may help lower the cost of a medication to a price that is more affordable than the copay with insurance.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
...(Except Major Holidays)
© 2024 SingleCare Administrators. All Rights Reserved.
* Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price.
Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
This is a prescription discount plan. This is NOT insurance nor a Medicare prescription drug plan. The range of prescription discounts provided under this discount plan will vary depending on the prescription and pharmacy where the prescription is purchased and can be up to 80% off the cash price. You are fully responsible for paying your prescriptions at the pharmacy at the time of service, but you will be entitled to receive a discount from the pharmacy in accordance with the specific pre-negotiated discounted rate schedule. Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.Towers Administrators LLC (operating as 'SingleCare Administrators') is the authorized prescription discount plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services LLC ('SingleCare') is the vendor of the prescription discount plan, including their website.website at www.singlecare.com. For additional information, including an up-to-date list of pharmacies, or assistance with any problems related to this prescription drug discount plan, please contact customer service toll free at 844-234-3057, 24 hours a day, 7 days a week (except major holidays). By using the SingleCare prescription discount card or app, you agree to the SingleCare Terms and Conditions found at https://www.singlecare.com/terms-and-conditions
© 2024 SingleCare Administrators. All Rights Reserved.