What is Tysabri: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 30, 2020

Tysabri overview

BRAND NAMES:

  • Tysabri

Generic Names:

  • Tysabri

Uses:

  • Treats Crohn disease and multiple sclerosis (MS).

Therapeutic Classes:

  • Central Nervous System Agent, Immune Modulator, Immune Suppressant

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Tysabri used for?

Tysabri is a monoclonal antibody used to treat patients with multiple sclerosis. This medication works by attacking the body's immune system to destroy the damaged cells and protect the healthy ones. Tysabri may also be used to treat adults with mild to severe case of Crohn's disease.

What form(s) does Tysabri come in

  • Injectable

What are common Tysabri doses?

  • Vial 15ML of 300MG/15ML

Common Tysabri prescriptions

  • Tysabri
    15ml of 300mg/15ml vial

How to take Tysabri

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • This medicine must be injected slowly, so the needle will have to remain in place for about an hour.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Missed dose:Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose:Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • This medicine must be injected slowly, so the needle will have to remain in place for about an hour.

Tysabri contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to natalizumab, or if you have had progressive multifocal leukoencephalopathy (PML).

Tysabri warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, a fever, or any kind of infection (including herpes infection). Tell your doctor if you have a weak immune system (that may be caused by HIV/AIDS, cancer, or an organ transplant).

  • This medicine may cause the following problems:Infections of the brain or nervous system, including PML, encephalitis, retinal necrosis, or meningitisLiver problems

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

  • You may need to have an MRI scan before you start receiving this medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Tysabri interactions

  • Some medicines can affect how natalizumab works. Tell your doctor if you are using medicine that weakens your immune system, including azathioprine, cyclophosphamide, cyclosporine, mercaptopurine, methotrexate, mitoxantrone, mycophenolate mofetil, or steroid medicine.

  • This medicine may cause the following problems:Higher risk for infectionsInfections of the brain or nervous system, including PML, encephalitis, or meningitisLiver damage

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

  • You may need to have an MRI scan before you start using this medicine.

Tysabri side effects

Serious Side Effects

  • Warmth or redness in your face, neck, arms, or upper chest, dizziness

  • Weakness on one side of your body, clumsiness, trouble seeing or vision changes, confusion, memory problems, unusual behavior

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate, difficult or painful urination, bloody or cloudy urine

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fever, chills, runny or stuffy nose, cough, sore throat, body aches

  • Unusual bleeding, bruising, tiredness, or weakness

  • Vaginal itching, discharge, or bleeding

Less Serious Side Effects

  • Arm, leg, joint, or muscle pain

  • Diarrhea, stomach upset

  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed

  • Headache

  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed

  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed