What is Trelegy Ellipta: Uses, Warnings & Interactions

This medicine should come with an information leaflet and/or Medication Guide. Ask your pharmacist for a copy if you do not have one. Carefully read the prescription label as well as the patient information, and consult your healthcare provider if you have any questions.

Your doctor will tell you how much medicine to use, generally one puff by mouth daily. Do not use more than directed. Use this medicine at the same time each day.

To inhale this medicine, breathe out fully and try to get as much air out of your lungs as possible.

Put the mouthpiece between your lips and close your lips firmly around it. Take one long, steady, deep breath in through your mouth. Do not breathe in through your nose or block the air vent with your fingers.

Remove the inhaler from your mouth, hold your breath for about 3 to 4 seconds, and breathe out slowly. You may not taste or feel the medication, even if you use the inhaler correctly.

Rinse your mouth out with water, then spit. Do not swallow. This helps prevent fungal infections of the mouth and throat. 

You may clean the mouthpiece using a dry tissue, if needed, before closing the cover.

Each time you open the cover of the inhaler and hear a click, the inhaler is ready to use. Do not close the cover until you have taken your dose. You will lose the dose if you open and close the cover without inhaling the medicine.

Store at room temperature, away from heat, moisture, and direct light. Throw away this medicine 6 weeks after it was opened or when the counter reads "0."

The inhaler has a window that shows the number of doses remaining. This tells you when you are getting low on medicine. The left half of the counter will turn red when there are less than 10 doses left to remind you to refill your prescription.

This medicine is a powder that is used with its own inhaler device. Keep the medicine in the foil tray until you are ready to use the inhaler.

Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Do not take more than 1 inhalation per day.

This medicine is not right for everyone. You should not take Trelegy Ellipta if you are allergic to fluticasone, umeclidinium, vilanterol, or milk proteins. Do not use this medicine during an acute asthma attack or an acute COPD flare-up.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Do not use this medicine to treat acute attacks. You should have a rescue medicine to use for an acute asthma attack or COPD flare-up, such as albuterol. Tell your doctor right away if your condition gets worse or you need to use your other medicine more often than usual.

Keep all medicine out of the reach of children. Never share your medicine with anyone, even if they have the same symptoms.

Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart disease, asthma, high blood pressure, heart rhythm problems, any infection (including tuberculosis, herpes infection of the eye), seizures, thyroid problems, diabetes, trouble urinating, an enlarged prostate, bladder blockage, a recent exposure to measles or chickenpox, or a history of cataracts, glaucoma, or osteoporosis.

This medicine may cause the following problems:

• Increased risk of infections, including pneumonia

• Adrenal gland problems

• Increased risk of paradoxical bronchospasm (trouble breathing right after use)

• Changes in heart rhythm

• Low bone mineral density, which may lead to osteoporosis

• Glaucoma or cataracts

• Slowed growth in children

Some medicines can affect how fluticasone/umeclidinium/vilanterol works. Tell your doctor about all of the medications you take, including if you are using any of the following:

• Conivaptan

• Nefazodone

• Beta-blockers such as atenolol or metoprolol

• Diuretics (water pills) such as hydrochlorothiazide

• Medicine to treat HIV/AIDS (including atazanavir, lopinavir, nelfinavir, ritonavir, saquinavir)

• Antifungals such as ketoconazole or itraconazole

• Macrolide antibiotics like azithromycin or clarithromycin

• A tricyclic antidepressant or MAO inhibitor within the past 2 weeks

Do not use this medicine together with another inhaler that contains vilanterol or similar inhaled medicines, including arformoterol, formoterol, or salmeterol.

This is not a full list of drug interactions, and others may occur. Consult your healthcare provider regarding drug interactions and how they may affect you.