What is Promethegan: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 30, 2020

Promethegan overview

BRAND NAMES:

  • Phenadoz, Phenergan, Promethegan

Generic Names:

  • Promethazine Hcl

Uses:

  • Treats allergies and motion sickness. Also used before and after surgery and other procedures as a sedative and to control pain or nausea and vomiting. This medicine is a phenothiazine.

Therapeutic Classes:

  • Antiemetic, Antivertigo, Gastrointestinal Agent

Forms:

  • Suppository

How it’s taken:

  • Into the rectum

What is Promethegan used for?

Phenergan is an antihistamine used to treat patients with allergic rhinitis, nausea and vomiting. It is also used to treat motion sickness. This medication may also be used as a sleeping aid. Phenergan lowers the level of histamine in the body. It is indicated for use by patients 2 years and older. This medication is available as an injection.

What form(s) does Promethegan come in

  • Suppository

What are common Promethegan doses?

  • Box 12 Suppository

Common Promethegan prescriptions

  • Promethegan
    1000 suppository box

  • Promethegan
    12 suppository box

How to take Promethegan

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Rectal routeWash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.

  • Rectal routeLie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.

  • Rectal routeKeep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

  • Rectal routeTo make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).

  • Rectal routeNever take rectal suppositories by mouth.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Rectal routeYou may store the suppositories in the refrigerator, but do not freeze them.

  • Rectal routeKeep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Rectal routeLie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.

  • Rectal routeNever take rectal suppositories by mouth.

  • Rectal routeYou may store the suppositories in the refrigerator, but do not freeze them.

  • Rectal routeTo make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).

  • Rectal routeWash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.

Promethegan contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to promethazine or another phenothiazine medicine, or while you are having asthma symptoms or similar breathing problems.

Promethegan warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart or blood vessel disease, glaucoma, a stomach ulcer, bowel problems, an enlarged prostate, bone marrow problems, trouble urinating, or seizures. Also tell your doctor if you have breathing problems, such as COPD, asthma, or sleep apnea.

  • This medicine may cause the following problems:Breathing problems, which could be life-threateningNeuroleptic malignant syndrome (a nerve disorder that can be life-threatening)Liver problems

  • Use in children: Give the medicine exactly as directed by the child's doctor. Too much of this medicine can cause death in a young child. Do not give this medicine to a child younger than 2 years old, unless your doctor tells you to.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Yellow skin or eyes

Promethegan interactions

  • Some medicines can affect how promethazine works. Tell your doctor if you are also using an MAO inhibitor (MAOI).

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Use in children: Give the medicine exactly as directed by the child's doctor. Too much of this medicine can cause death in a young child. Do not give this medicine to a child younger than 2 years old, unless your doctor tells you to.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Promethegan side effects

Serious Side Effects

  • Seeing or hearing things that are not there (especially in children)

  • Twitching or muscle movements you cannot control

  • Lightheadedness or fainting

  • Trouble breathing, slow breathing

  • Seizures

  • Yellow skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fever, sweating, confusion, uneven heartbeat, muscle stiffness

Less Serious Side Effects

  • Nausea, vomiting, constipation

  • Blurred vision