Aleve, All Day Pain Relief, Ana-Dent, Anaprox DS (Rx), Calmadol, EC Naprosyn (Rx), Flanax, Mediproxen, Naprelan (Rx), Naprosyn (Rx), Naprotin (Rx), Proxen NP 660
Naproxen
Treats fever and pain. Also treats arthritis, gout, bursitis, tendonitis, menstrual cramps, and pain.
Nonsteroidal anti-inflammatory drug (NSAID), analgesic, antipyretic, antimigraine, antirheumatic, musculoskeletal agent, central nervous system agent
Tablet, long-acting tablet, coated tablet, liquid-filled capsule, oral suspension (liquid)
By mouth
Naproxen is a common over-the-counter pain reliever used to relieve minor aches and pains and reduce fever. Higher-dose prescription naproxen is used to relieve pain and other symptoms of arthritis, tendonitis, gout, and bursitis or to relieve menstrual pain.
Tablet
220 mg
250 mg (Rx)
375 mg (Rx)
500 mg (Rx)
Long-acting tablet
220 mg
250 mg (Rx)
375 mg (Rx)
500 mg (Rx)
750 mg (Rx)
Coated tablet
220 mg
275 mg (Rx)
550 mg (Rx)
Liquid-filled capsule
220 mg
Oral suspension (liquid)
125 mg/5 mL (Rx)
For minor aches and pains, fever, and menstrual cramps (OTC naproxen): 220 mg–440 mg taken every 8–12 hours as needed
For arthritis, inflammatory conditions, pain, or menstrual cramps (Rx naproxen): 250 mg–500 mg every 12 hours (375–500 mg DR naproxen every 24 hours)
For gout (Rx naproxen): 250 mg every 8 hours
Naproxen
500ml of 125mg/5ml bottle
Naproxen
250mg tablet
Naproxen
375mg tablet
Naproxen
500mg tablet
Naproxen
375mg tablet delayed release
Naproxen
500mg tablet delayed release
How to take over-the-counter naproxen
Follow the dosing directions on the medicine label.
Do not take more than directed. That means no more than two tablets every 8–12 hours and no more than three tablets every 24 hours.
Drink a glass of water when taking tablets or liquid-filled capsules.
To avoid side effects, use the lowest effective dose for the shortest time possible.
Store the drug at room temperature. Avoid high heat or high humidity.
How to take prescription naproxen
Follow the directions given by the prescribing healthcare provider.
This medicine should include an NSAID Medication Guide. If it’s missing, a pharmacist can provide one.
Do not take more than directed and do not take the drug more often than directed.
Drink a glass of water when taking tablets.
Do not crush, chew, or break delayed-release tablets.
Store prescription naproxen tablets at room temperature in a closed container.
How to take liquid naproxen
Naproxen oral solution is only available with a prescription. Follow the directions given by the prescribing healthcare provider.
This medicine should include a Medication Guide with detailed instructions on how to take or give a dose. If it’s missing, ask the pharmacist for a copy.
Shake the solution well before measuring out a dose.
Use a calibrated syringe or similar measuring device to measure the dose. Do not use kitchen utensils.
Naproxen oral suspension can be stored at room temperature. Avoid exposing it to high heat.
Over-the-counter naproxen is taken on an as-needed basis. If a dose is missed it can be taken when remembered. Do not take more than two tablets every 8–12 hours.
For prescription naproxen, ask a healthcare provider about what to do in case a dose is missed. You can take the missed dose when remembered, but that may reset the dosing schedule.
Do not use naproxen if you have ever had an allergic reaction to naproxen, aspirin, or other NSAIDs.
Naproxen should not be taken before or after heart surgery.
Use OTC naproxen cautiously. Take the lowest possible dose for the shortest possible time.
If OTC naproxen does not relieve pain in 10 days or fever in 3 days, contact a doctor.
Because of possible side effects, healthcare providers are urged to prescribe the lowest possible dose for the shortest possible time.
The doctor may require regular blood tests to make sure meloxicam treatment is not causing problems. Keep all appointments.
Naproxen increases the risk of blood clots, heart attack, stroke, heart failure, and edema.
Naproxen can cause serious gastrointestinal problems including ulcers, bleeding, and perforation of the stomach, esophagus, or intestines.
NSAIDs like naproxen may cause severe allergic or skin reactions. If an allergic reaction occurs, stop taking meloxicam immediately and contact your doctor.
Tell the doctor prescribing naproxen if you have any of the following conditions:
Heart disease
Recent heart attack
Heart failure
History of ulcers
History of gastrointestinal bleeding
Kidney disease
Liver disease
Asthma
High blood pressure
Blood vessel problems
Bleeding problems
Dehydration
Pregnancy or plans to get pregnant
Breastfeeding
Naproxen can cause
Kidney damage
Liver damage
High blood pressure
High potassium
Anemia
Naproxen may cause dizziness or drowsiness. Do not drive or engage in risky activities until you’re confident about side effects.
Naproxen can delay ovulation in women.
Because of possible risks to an unborn child, NSAIDs should not be taken after the 20th week of pregnancy.
Your headaches may become worse if you use an NSAID for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.
Because of possible drug interactions, tell healthcare providers you are using this medicine, especially if you have surgery or a procedure.
Avoid taking other NSAIDs such as aspirin or ibuprofen with naproxen. The prescription NSAID ketorolac should never be combined with naproxen.
Avoid alcohol if you’re taking naproxen or another NSAID.
Other medications that may cause problems with naproxen include:
Blood thinners
Blood pressure medications
Antidepressants called SSRIs or SNRIs
Corticosteroids
Diuretics
Antacids
Certain types of cholesterol drugs called bile acid sequestrants
Certain types of antibiotics called aminoglycoside antibiotics
Digoxin, lithium, pemetrexed, probenecid, methotrexate, and cyclosporine
Naproxen can cause serious side effects. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect including:
Severe stomach pain, vomiting blood, bloody stools, or black and tarry stools
Chest pain, trouble breathing, weakness on one side of your body, severe headache, trouble seeing or talking, pain in your lower leg
Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness
Swelling in your hands, ankles, or feet, rapid weight gain
Changes in how much or how often you urinate
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Bleeding and bruising
High blood pressure
High potassium
Trouble seeing, blind spots, change in how you see colors
Hearing loss
Allergic reactions: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, or red skin rash
Less serious side effects
Headache
Stomach upset
Nausea
Gas
Flu
Diarrhea
Drowsiness
Dizziness
Ringing in the ears
Rash
Back pain
Nasal congestion
Sore throat
Constipation
Aleve caplets drug information, NIH National Library of Medicine
Naproxen sodium tablets prescribing information, NIH National Library of Medicine
Naproxen oral suspension, NIH National Library of Medicine
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