What is Myfembree: Uses, Warnings & Interactions

Updated Jul 20, 2021  •  Published Jul 19, 2021

Myfembree overview

BRAND NAMES:

  • Myfembree

Generic Names:

  • Myfembree

Uses:

  • Treats heavy menstrual bleeding caused by uterine fibroids.

Therapeutic Classes:

  • Endocrine-Metabolic Agent, Estrogen/Progestin Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What form(s) does Myfembree come in

  • Tablet

What are common Myfembree doses?

  • Tablet 40-1-0.5MG

How to take Myfembree

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Take the tablet at about the same time each day.

  • You may receive other medicines (including calcium or vitamin D supplements) to help reduce bone loss.

  • Use this medicine within 7 days from the start of your menstrual period.

Myfembree contraindications

  • This medicine is not right for everyone. Do not use it if you have had an allergic reaction to relugolix, estradiol, or norethindrone, or if you are pregnant. Do not use it if you have vaginal bleeding that has not been checked by a doctor, liver disease, uncontrolled high blood pressure, problems with blood clots, breast cancer, migraine headaches, or osteoporosis (weak bones).

Myfembree warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may cause the following problems:Increased risk of blood clots, heart attack, or strokeLower bone mineral densityIncreased risk of breast cancerChanges in mood or behavior, including thoughts of suicideLiver problemsGallbladder diseaseHigh blood pressureChanges in menstrual bleeding, which may decrease the ability to know if you are pregnantHair lossHigh cholesterol and blood sugar

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. This medicine may increase your risk of early pregnancy loss. Your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) during treatment and for at least 1 week after the last dose.

  • Tell your doctor if you are breastfeeding, or if you have blood vessel disease, high cholesterol, diabetes, mental problems, gallbladder problems, jaundice (yellow skin or eyes) caused by pregnancy or birth control pills, or a history of fractures. Tell your doctor if you smoke or if you will be having a surgery.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

Myfembree interactions

  • Take this medicine at least 6 hours before taking other medicines called P-gp inhibitors. Ask your doctor about these medicines.

  • Some medicines can affect how relugolix/estradiol/norethindrone works. Tell your doctor if you are using erythromycin or rifampin.

Myfembree side effects

Serious Side Effects

  • Breast lumps, pain, swelling, tenderness, or discharge

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Thinning or loss of hair

  • Dry mouth, increased hunger, thirst, or urination

  • Sudden or severe headache, problems with vision, speech, or walking

  • Stomach pain, nausea, vomiting, lightheadedness

  • Light, heavy, or irregular bleeding during monthly periods

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg (calf)

  • Bone pain, decreased height

  • Dark urine or pale stools, loss of appetite, yellow skin or eyes

  • Chest pain or tightness, trouble breathing, coughing up blood

  • Extreme energy or restlessness, confusion, agitation, unusual mood or behavior, thoughts or attempts at killing oneself

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Decreased interest in sex

  • Feeling of warmth, redness of the skin, sweating