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Shingles Treatments and Medications

Medically reviewed by Raymond ZakhariDNP, EdM, NP-BC
Triple Board-Certified Nurse Practitioner
Updated Mar. 30, 2022  •  Published Jun. 25, 2020
Fact Checked

What is shingles?

Shingles (herpes zoster) is caused by the varicella-zoster virus, which is the same virus that causes chickenpox. Unfortunately, you’re at risk for shingles if you’ve had chickenpox before.

After having chickenpox, this virus may remain dormant for many years before any symptoms of shingles appear. The first sign of shingles is a painful rash, usually on one side of your body or face.

Although preventable by vaccine, shingles is common in the United States. There are more than 200,000 cases of shingles every year. Half of these cases occur in older adults over the age of 60, according to the Centers for Disease Control and Prevention. Symptoms of shingles are treatable, however, the virus is not yet curable.

In this article, we’ll explain the different types of shingles treatment that your healthcare provider may prescribe or recommend, including topical creams, oral medications, the shingles vaccine, and other pain relief tips you can try at home.

How is shingles diagnosed?

Schedule an appointment with your primary care provider or urgent care facility if you experience any symptoms of shingles (most commonly a painful skin rash). You may require immediate medical attention if shingles develops in the eye, if it is widespread across the body, if you’re 60 years old or older, or if you have a weakened immune system from another chronic illness. Consider contacting an ophthalmologist for urgent care as you may be able to get an appointment sooner.

Your primary care provider can diagnose shingles. However, if symptoms appear in the eye, then you might need to see an ophthalmologist.

Shingles can usually be diagnosed with a simple physical exam, as symptoms are usually distinctive. However, if your symptoms are atypical, your doctor may send a tissue scraping or culture from the blisters to the lab for testing. Blood, cerebrospinal fluid, or saliva tests may be necessary if you have nerve pain without a skin rash.

Your healthcare provider may also ask the following questions to help confirm the diagnosis:

  • Have you had chickenpox before?
  • Are you over the age of 60?
  • Have you had the shingles vaccine?
  • Are you stressed?
  • Do you have a chronic illness or are you taking medications (steroids, autoimmune disease medications, antirejection medications for transplant, or chemotherapeutic agents) that could weaken your immune system?

Shingles treatment options

Although some natural solutions and home remedies may help you prevent another shingles episode or alleviate postherpetic neuralgia pain, you should consult your doctor as soon as shingles symptoms appear.

Even though shingles is not completely curable, your doctor will be able to prescribe a medication to relieve your pain and shorten the duration of your symptoms. To get rid of shingles fast, antiviral drugs may alleviate symptoms within three days, according to The National Institutes of Health (NIH).

Shingles medications

Antiviral medication and vaccinations are often the most effective shingles treatments, according to the National Foundation for Infectious Diseases. Here are some of the most popular shingles medications:

Zovirax (acyclovir)

Zovirax is a brand-name prescription drug that's manufactured by GlaxoSmithKline. Generic acyclovir is also available. It may be prescribed to adults and children at least 12 years of age.

This antiviral medication reduces the severity and duration of shingles episodes. It helps blisters heal faster while preventing new blisters from developing. It also relieves symptoms like burning and itching.

Zovirax (acyclovir) is available as an oral tablet, capsule, or liquid that’s taken up to five times a day. It’s also available as a topical cream that’s applied every three to four hours.

Digestion-related side effects, like nausea, diarrhea, or vomiting, may occur. Headaches are also common.

Valtrex (valacyclovir)

Valtrex is another brand-name medication that’s manufactured by GlaxoSmithKline. The generic version of Valtrex is called valacyclovir. It may be prescribed to adults and children above the age of 12.

Like acyclovir, valacyclovir helps stop the growth of viral infections. It is not a cure for shingles, but it relieves painful symptoms of shingles rashes while preventing new blisters from forming.

It is available as an oral tablet only in the following strengths: 1 gm and 500 mg. Your healthcare provider will determine the right dosage for you depending on your condition, response to treatment, age, and weight. You should drink plenty of water while taking Valtrex (valacyclovir).

Nausea and stomach pain may occur. Valtrex (valacyclovir) might also make you feel lightheaded. Tell your doctor if these side effects continue or worsen.

Famvir (famciclovir)

TEVA Pharmaceuticals manufactures the brand-name drug, Famvir. Famciclovir is the generic version. A doctor may prescribe this medication to adults between the ages of 18 and 65. This may not be the best shingles treatment for patients older than 65 if the patient has renal function problems.

Like the antiviral medications above, Famvir (famciclovir) cannot cure shingles but it can reduce the pain and duration of symptoms. It could also prevent the virus from spreading to other parts of the body.

Famvir (famciclovir) is available as a tablet in strengths of 125 mg, 250 mg, or 500 mg. It is taken by mouth, usually two to three times per day at the first sign of a shingles outbreak.

Common side effects of this antiviral medication include headache, nausea, and diarrhea.

Shingrix

GlaxoSmithKline manufactures the new shingles vaccine called Shingrix. A generic vaccine is not available, as Shingrix was just released in 2017. Most drug patents last 20 years.

Shingrix contains inactivated varicella-zoster, which aids the body’s production of more antibodies than are necessary to fight the virus with a stronger immune system response. As an inactive vaccine, it may be administered to patients with compromised immune systems. It reduces the risk of getting shingles by more than 90% and it’s effective for five years.

Two doses are required for Shingrix to be effective. The second dose should be injected within two to six months of the first dose. Both doses are injected into the muscle. It’s recommended for patients who are at least 50 years old.

Normal side effects include muscle pain, tiredness, fever, and gastrointestinal symptoms. An allergic reaction is possible. Seek emergency medical attention if you experience difficulty breathing, swelling of the face, or severe dizziness.

Zostavax

The Zostavax vaccine was developed by Merck & Co. and approved by the FDA in May 2006. However, it wasn't approved for use in patients between the ages of 50 and 59 until 2011.

Zostavax contains a live but weakened version of the varicella-zoster virus. Although 19 times stronger than the chickenpox vaccine, Zostavax is less effective than Shingrix. It reduces the risk of shingles by 51% and of prolonged pain by 67%. However, your doctor may prefer that you receive the Zostavax vaccine instead of Shingrix, so consult your healthcare provider for medical advice first.

Only one dose of Zostavax is required. It’s recommended for patients who are at least 60 years old.

Zostavax causes fewer side effects than Shingrix. Injection site reactions are the most common side effect, but a headache, diarrhea, and body aches are also possible. You can get Shingrix at your local pharmacy but be aware this medication is often on backorder and not on the shelves so you may have to shop different pharmacies to see which has Shingrix in stock.

What is the best medication for shingles?

Your healthcare provider will determine the best medication for your case of shingles based on your symptoms, medical history, and response to shingles treatment. Here’s an overview of the popular shingles medications that your doctor may prescribe.

Best medication for shingles
Drug Name Drug Class Administration Route Standard Dosage Side Effects
Zovirax (acyclovir) Antiviral Topical 5% topical cream applied to the affected area every 3-4 hours Nausea, diarrhea, headache, or vomiting
Zovirax (acyclovir) Antiviral Oral 1, 400 mg tablet taken 2-5 times daily Nausea, diarrhea, headache, or vomiting
Valtrex (valacyclovir) Antiviral Oral One one-gram tablet taken at the same time each day as soon as symptoms appear Nausea, stomach pain, headache, or dizziness
Famvir (famciclovir) Antiviral Oral 1, 500 mg tablet 2-3 times daily Nausea, diarrhea, or headache
Shingrix (zoster vaccine inactivated) Vaccine Injectable 2, 0.5 ml injections that are 2-6 months apart Muscle aches, headaches, fatigue, or upset stomach
Zostavax (zoster vaccine live) Vaccine Injectable One 0.65 ml injection in the upper arm Irritation of the injection site or chickenpox-like rash near the injection site or headache

Dosage is determined by your healthcare provider based on your medical condition, response to treatment, age, and weight.

Other possible side effects exist. This is not a complete list.

What are common side effects of shingles medication?

Gastrointestinal (GI) side effects are common across shingles medications. These include nausea, diarrhea, upset stomach, and vomiting. It’s important to stay hydrated while taking medications that cause these side effects, as dehydration could be more dangerous than the virus itself.

This is not a full list of side effects. Ask a healthcare professional, such as your physician or pharmacist, for more details regarding the possible side effects of your particular medication.

How can I treat shingles naturally?

The shingles virus affects the nerves, which is why a skin rash only appears in a specific area of the body rather than all over. However, nerve pain is still possible even after the shingles rash has disappeared. If the nerve fibers are damaged, they are unable to send messages from your skin to your brain. This complication of shingles is called postherpetic neuralgia (PHN) and it can cause severe pain, lasting months or even years.

Postherpetic neuralgia is more common in the following patients:

  • Adults over the age of 50
  • Patients with another medical condition, like diabetes
  • Those who experienced a severe shingles rash
  • Those who experienced a shingles rash on the face or torso
  • Patients who didn’t begin shingles treatment within 72 hours of symptoms appearing

Besides chronic pain, symptoms of postherpetic neuralgia include depression, insomnia, suppressed appetite, and attention deficits. Fortunately, there are home remedies, over-the-counter products, and prescription medications that offer pain relief to these symptoms. Here’s a long list of treatments:

Frequently asked questions about shingles

How long does shingles last?

The shingles virus lasts a lifetime. However, it may remain inactive for many years at a time. A shingles attack or episode may last between two and four weeks. Here is an average timeline:

  1. Pain begins on a specific area of one side of the body or face.
  2. A red, blotchy rash appears within five days.
  3. The rash blisters. These blisters may merge and form a solid band of inflammation.
  4. New blisters may form throughout a week’s time.
  5. Blisters will eventually dry and scab after seven to 10 days. Minor scarring is possible.

What brings on an attack of shingles?

It’s difficult to predict when a shingles episode might happen again. However, there are some risk factors you should consider.

  • Age
  • Weakened immune system
  • Unhealthy lifestyle
  • Acute on chronic stress

The first risk factor is age. If you are above the age of 50, ask your doctor about the shingles vaccine. In addition to being an effective shingles treatment, this vaccine is used to prevent shingles.

The second risk factor of shingles is immunity. If your immune system is weakened by illness or medication, you are at risk for contracting shingles or experiencing another shingles episode. Fortunately, you can naturally strengthen your immune system with the right diet and vitamins.

Citrus fruits, green vegetables, organic meat, eggs, whole grains, and dairy products are all part of a healthy diet. You should avoid sugar, refined carbohydrates, saturated fat, and arginine-rich foods, like nuts and seeds.

Additionally, take a multivitamin that includes vitamin A, B-12, C, and E. The amino acid lysine is also protective against infection. Many people over the age of 60 are deficient in zinc, selenium, and vitamin D. You may need to incorporate these supplements into your daily routine as well. Ask your healthcare provider for recommendations as to which vitamins and supplements you need.

The third risk factor for shingles is an unhealthy lifestyle. Stress, smoking, and sedentary living can weaken anyone’s immune system and cause a slew of medical conditions. To protect your immune system and prevent another shingles episode, you may have to employ relaxation methods, join a smoking cessation support group, or incorporate more exercise into your everyday life.

How long is shingles contagious?

The varicella-zoster virus is contagious and can be spread from someone who has chickenpox or shingles. Although shingles is a lifelong disease, it is only contagious for some time during each episode. Shingles is contagious from the time your symptoms appear until the time that your blisters have dried or crusted, which usually happens within seven to 10 days of symptoms appearing. As long as the blistered area is covered and hands are clean the spread is contained.

How does shingles spread?

Someone with shingles can pass the virus to someone who hasn’t had chickenpox or shingles before. That person is likely to contract chickenpox first. Then, the virus may reactivate later with symptoms of shingles.

The virus cannot be passed to someone who has already had chickenpox because they already have the virus. If they experience shingles, it’s because they already had the virus—not because they came into contact with you.

You can go to work, school, and other public places with shingles as long as you’re otherwise healthy. However, you should take precautions and keep the shingles rash covered, regularly wash your hands, and avoid at-risk people. Infants, children, pregnant women, and people with weak immune systems are at higher risk for contracting a virus, like shingles, than other people.

Medically reviewed by Raymond ZakhariDNP, EdM, NP-BC
Triple Board-Certified Nurse Practitioner

Raymond Zakhari, DNP, EdM, NP-BC, is a triple board certified nurse practitioner with a diverse clinical background ranging from Intensive Care to medical house calls. He began his career at Duke University Medical center in the cardiothoracic ICU and made his way back to the northeast as a traveling ICU and ER nurse. In 2009 he founded Metro Medical Direct, the first concierge, nurse practitioner owned, medical/ psychiatric house calls and tele-health practice in New York City. Dr. Zakhari was also trained in sex therapy at the New York University School of Medicine/Langone Medical Center and is appointed to the staff of New York PresbyterianHospital, department of internal medicine in psychiatry at the Payne Whitney Clinic. He provides consultative services as a Sexual Assault Forensic Examiner. He is a former officer of the New Jersey Air National Guard and has deployed in support of Operation Iraqi Freedom. He has held adjunct faculty appointments at the Hunter Bellevue School of Nursing, New York University, and Liberty University. Dr. Zakhari hosts a podcast called The Psychology of it All. Over the years, Dr. Zakhari has published in peer-reviewed journals and has presented at both regional and national conferences. He currently is a member of the American Academy of Nurse Practitioners (AANP), the Society for Sex Therapists and Researchers (SSTAR), and the International Association of Forensic Nurses.

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