Sciatica, medically known as lumbar radiculopathy, is caused by pressure on or irritation of the sciatic nerve roots located in the lower lumbar spine. This pressure causes severe pain, numbness, and weakness that starts in the lower back and radiates down, causing leg pain. It can also cause chronic low back pain. It is a common condition, with between 10 and 40 percent of the population in the United States, experiencing symptoms of sciatica at some point in their lives, according to a report published in 2019. Both men and women are equally likely to develop sciatica. Treatment includes a combination of physical therapy, at-home remedies, and medication when needed.
Although you can develop sciatica at any age, it most often shows up during the 40s. It occurs in both men and women. One possible cause is a genetic predisposition, according to a few studies, although other studies have not found this to be significant. Commonly known risk factors for the development of sciatica include personal factors (e.g., smoking, stress, height, and age group). Some common causes of sciatica, according to a report published in the British Medical Journal include:
Some women experience sciatica symptoms during pregnancy due to the growing uterus pressing against the sciatic nerve. Certain occupations can increase the risk of developing sciatica. For example, sitting for long periods can place pressure on the spinal cord nerves, such as truck drivers and machine operators (who experience prolonged whole-body vibration).
Many people seek medical advice for sciatica pain relief if at-home remedies, such as applying heat and over-the-counter pain relievers, do not help alleviate symptoms. Your family physician might treat your sciatica or could refer you to a specialist, such as a neurologist, physical therapist, or pain management physician.
Your doctor will start by asking you questions about your sciatic symptoms, such as whether it starts or worsens after specific activities. They also do a physical examination, which can include checking muscle strength and reflexes. Your doctor might ask you to perform certain physical activities, such as lifting one leg at a time, getting up from squatting position, standing from lying down, walking on heels or toes. Pain from sciatica often worsens during these activities.
Sometimes doctors diagnose sciatica based on a physical evaluation and your description of symptoms. If the pain does not go away or if it is severe, your doctor may order tests such as X-ray, MRI, CT scan, electromyography. These tests are used to determine underlying causes, such as bone spurs, disc herniation, nerve compression, or lumbar stenosis.
Sciatica shares symptoms with piriformis syndrome. Spasms of the piriformis muscle, located in the buttocks, irritate the sciatic nerve, causing numbness and tingling as well as pain down the back of the leg. Treatment for this condition includes a combination of physical therapy, heat/cold therapy, corticosteroid injections, or Botox injections.
Some questions to ask your doctor after being diagnosed with sciatica:
Treatment of sciatic nerve pain usually includes a combination of over-the-counter medications and home care. For about 80 to 90 percent of those with acute sciatica, symptoms resolve themselves within several weeks, according to the American Academy of Orthopaedic Surgeons (AAOS).
Chronic sciatica is a life-long condition, and doctors might suggest more aggressive treatment. Although the pain with chronic sciatica is usually milder, it might require treatment during flare-ups. There are several treatment options, including home care, medications, corticosteroid injections, physical therapy, and surgery. Several conditions that can cause sciatica improve with surgery, such as herniated disc, spinal stenosis, spondylolisthesis, and a tumor on the spine. However, surgery is generally a last resort, according to John Hopkins Medicine.
Medical therapies to help manage sciatica pain include:
There are five types of drugs used to treat sciatica. They include:
There are many different choices of treatments for sciatica, and there is no "best" medication. What works for one person might not work for another. Everyone reacts differently to medicines, and it sometimes takes time to find the right drug and the correct dosage for you. Your doctor will take your medical condition, medical history, and other medication you are taking into consideration when suggesting a treatment for you.
Best medications for sciatica | ||||||
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Brand name (generic) | Drug class | OTC or prescription | Methods of use | Standard dose | Pain relief or preventive | Common side effects |
Motrin (ibuprofen) | NSAID | OTC (also available at higher dosage by prescription) | Tablet or caplet | 200 mg every 4-6 hours as needed | Pain relief | Stomach upset |
Aleve (naproxen) | NSAID | OTC (also available at higher dosage by prescription) | Tablet or capsule | 220 mg every 8-12 hours as needed | Pain relief | Stomach upset |
Aspirin | NSAID | OTC | Tablets, chewable tablets | 300-650 mg every 4-6 hours as needed | Pain relief | Stomach upset, ringing in ears, tendency to bleed more |
Tylenol (acetamenophin) | Pain reliever | OTC | Tablets, caplets | 325-650 mg every 4-6 hours as needed. Not to exceed 3250 mg per day | Pain relief | Liver problems |
Lioresal (baclofen) | Muscle Relaxant | Prescription | Tablet | Gradually increases in 5 mg intervals from 5 mg to 20 mg 3x day for 3 days | Pain relief | Confusion, dizziness, drowsiness, nausea |
Soma (carisoprodol) | Muscle Relaxant | Prescription | Tablet | 250-350 mg 3x day. Can be habit-forming, use short term only | Pain relief | Drowsiness, dizziness, headache |
Lorzone (chlorzoxazone) | Muscle Relaxant | Prescription | Tablet | 375 mg up to 4x day | Pain relief | Drowsiness, dizziness, nervousness, potential for liver problems |
Fexmid (cyclobenzaprine) | Muscle Relaxant | Prescription | Tablet, capsule | 5 mg up to 3x day | Pain relief | Blurred vision, drowsiness, dry mouth |
Dantrium (dantrolene) | Muscle Relaxant | Prescription | Capsule | Gradual increase from 25 mg 1x day for 7 days to 100 mg 3x day | Pain relief | Diarrhea, dizziness, drowsiness, muscle weakness |
Skelaxin (metaxalone) | Muscle Relaxant | Prescription | Tablet caplet | 800 mg 3-4x day | Pain relief | Drowsiness, irritability, stomach upset |
Robaxin, Robaxin-750(methocarbamol) | Muscle Relaxant | Prescription | Tablet | 1500 mg 4x day | Pain relief | Headache |
Zanaflex (tizanidine) | Muscle Relaxant | Prescription | Tablet, capsule | 2 mg every 6-8 hours as needed | Pain relief | Bradycardia, dizziness, hypotension |
Elavil (amitriptyline) | Tricyclic antidepressants | Prescription | Tablet | 10-25 mg per day | Preventative | Tremors, dizziness, headache, dry mouth |
Pamelor (nortriptyline) | Tricyclic antidepressants | Prescription | Capsule | 25 mg daily, increasing by 25 mg weekly if needed to 100 mg | Preventative | Rapid heartbeat, dry mouth, urinary retention |
Vivactil (protriptyline) | Tricyclic antidepressants | Prescription | Coated tablet | 5 mg 3x day, gradually increased to 40 mg if necessary | Preventative | Drowsiness, dry mouth, blurred vision |
Silenor (doxepin) | Tricyclic antidepressants | Prescription | Tablet | 1-6 mg per day | Preventative | Constipation, dry mouth, drowsiness |
Tofranil (imipramine) | Tricyclic antidepressants | Prescription | Tablet, capsule | 10-50 mg per day | Preventative | Tremors, weight gain, dry mouth, constipation |
Anafranil (clomipramine) | Tricyclic antidepressants | Prescription | Capsule | 25 mg per day | Preventative | Sexual problems, fatigue, headache |
Norpramin (desipramine) | Tricyclic antidepressants | Prescription | Tablet | 25 mg per day | Preventative | Tremor, dizziness, dry mouth |
Gralise, Neurontin, Horizant (gabapentin) | Anticonvulsants | Prescription | Tablet, extended-release tablet | 400 mg increased by 300 mg incrementally to 2400 mg | Preventative | Drowsiness, ataxia, dizziness |
Lyrica (pregabalin) | Anticonvulsants | Prescription | Tablet, capsule, extended-release tablet and capsule | 150 mg per day increased to 300 mg 2x day | Preventative | Blurred vision, constipation, fatigue, headache |
Prednisone | Anti-inflammatory | Prescription | Tablets | 5-60 mg per day, then gradually decrease to the lowest dose that maintains desired response | Pain relief | Weight gain, insomnia, agitation |
Kenalog or Depo-Medrol | Anti-inflammatory | In the doctor’s office | Injection | Dosage varies | Preventative | Irritation at the site of injection, flushing of face |
The following is a list of some common side effects for sciatica medications. It is not a comprehensive list. Before taking any medication, you should consult with a medical professional about all the possible side effects and interactions with other medicines.
At-home care for acute sciatica or a flare-up of chronic sciatica includes:
There are also some lifestyle changes you can make to help prevent pain and flare-ups:
There is some research to indicate that natural treatments can be effective in managing pain from sciatica.
Deep tissue massage: A study from 2014 found that deep tissue massage might be as effective as NSAIDs for relieving low back pain. It relaxes muscles, which can reduce pressure on your sciatic nerve.
Yoga: Practicing yoga may help reduce pain, is generally safe, and is well received by participants according to a 2016 study.
Acupuncture: Two studies found acupuncture to be an effective treatment for sciatica. One indicated it is "more effective than traditional Western medicine." The other indicated it "may be more effective than drugs and may enhance the effect of drugs."
Chiropractic treatment: A chiropractor can adjust your spine to increase spinal movement and decrease pain according to a 2014 study.
Most of the time, sciatica goes away on its own, according to UT Southwestern Medical Center. For many people, acute sciatica will resolve itself within several weeks. Using over-the-counter NSAIDs and staying as active as possible can help you get through the flare of sciatica.
Sciatica can be either acute or chronic. An acute episode usually resolves itself within a few weeks. Some people experience several severe bouts of sciatica each year. Chronic sciatica is life long, and you can experience pain regularly, although the pain usually is milder than in an acute episode. Chronic sciatica doesn't respond well to treatment. Lifestyle changes, such as exercising daily, practicing yoga, and losing weight can help to reduce discomfort from chronic sciatica. Surgery is a last resort option if no other treatments provide enough relief, and the pain and discomfort interfere with your daily activities.
Each person reacts differently to medications, so there isn't one "best pain killer." For acute episodes, many people find over-the-counter NSAIDs relieve the pain. For chronic sciatica, some find tricyclic antidepressants or anticonvulsants are the best options. It may take some time to find the best treatment for you.
Anti-inflammatories, such as NSAIDs, help many people with sciatica. You should only take these on a limited basis. When taking for extended amounts of time, it is crucial to speak with your doctor. Some anti-inflammatories, such as steroids, are only available through your doctor, either orally or as an injection. Because inflammation puts pressure on your sciatic nerve, relieving the inflammation often helps ease the pain.
For acute episodes, cold packs or ice can reduce inflammation, alleviating some of the pain. Cold packs are best applied for the first two to seven days of an acute episode, according to Spine-Health.com. Once the acute pain has subsided, heat packs can be used to increase the flow of oxygen to the area.
Dr. Anis Rehman is an American Board of Internal Medicine (ABIM) certified physician in Internal Medicine as well as Endocrinology, Diabetes, and Metabolism who practices in Illinois. He completed his residency at Cleveland Clinic Akron General and fellowship training at University of Cincinnati in Ohio. Dr. Rehman has several dozen research publications in reputable journals and conferences. He also enjoys traveling and landscape photography. Dr. Rehman frequently writes medical blogs for District Endocrine (districtendocrine.com) and hosts an endocrine YouTube channel, District Endocrine.
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