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PTSD Treatments and Medications

Medically reviewed by Raymond ZakhariDNP, EdM, NP-BC
Triple Board-Certified Nurse Practitioner
Updated Aug. 1, 2023  •  Published Apr. 27, 2020
Fact Checked

Post-traumatic stress disorder (PTSD) can be a difficult and challenging condition to deal with. It can last for a few months, multiple years, or for life. PTSD is associated with nightmares, heightened reactions, loss of self-control, and anxiety. If you or a loved one has PTSD, read on to learn what the condition is, what the treatment options are, and how to live with the disorder.

What is PTSD?

PTSD is a psychiatric disorder that develops in some people who have experienced a highly traumatic experience or shocking and scary event, such as a natural disaster, sexual assault, terrorist attack, war, or other violent situation. Common symptoms include irritability or agitation, severe anxiety, insomnia, vivid flashbacks, nightmares, and emotional detachment. There are a variety of effective treatments that can help with PTSD, including cognitive behavioral therapy (CBT), group therapy, and medications like selective serotonin reuptake inhibitors (SSRIs).

This mental health condition is fairly common in the U.S., with more than three million cases occurring every year. There are many treatments that exist to combat the disorder. And, there are still new treatments that are in the experimental phase that may alleviate symptoms, such as stellate ganglion block (SGB) and MDMA-assisted psychotherapy.

How is PTSD diagnosed?

PTSD is caused by a traumatic event or series of traumatic events. Those at risk for PTSD include people who have experienced war, natural disasters, assault, or other triggering events. The most common symptoms that generally lead to a diagnosis include increased irritability, nightmares or insomnia, emotional detachment, and severe anxiety. However, a medical diagnosis is generally required to rule out other diseases and conditions.

You may have PTSD if the symptoms you experience from a tragic event or exposure continue for more than a month and cause problems in your ability to function in day-to-day life. If you’re not sure whether you have PTSD, schedule an appointment with your primary healthcare provider or a mental health professional right away, as he or she can help diagnose the issue and provide further medical advice.

Here’s what you can expect at your appointment:

  • Physical exam: Your healthcare provider will likely perform a physical exam to rule out any other diseases or conditions that could be causing your symptoms.
  • Psychological evaluation: Your healthcare provider may perform a psychological evaluation and ask you questions about any traumatic events you’ve experienced in the past. He or she may take note of any signs and symptoms you’re displaying during the evaluation.
  • Review of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria: Your healthcare provider may go through this list of criteria published by the American Psychiatric Association to help determine whether or not you have PTSD.

Questions the healthcare provider may ask you

During your appointment, your healthcare provider may ask the following questions to better inform the diagnosis of PTSD:

  • Have you experienced a life-threatening event that has caused fear, helplessness, or horror?
  • Do you have repeated memories of a stressful experience from your past?
  • How do you feel when you’re reminded of said stressful event?
  • Do you avoid activities or situations that remind you of a stressful event from the past?
  • Have you been isolating yourself from others?
  • Do you feel irritable or have outbursts?
  • Do you have difficulty concentrating on daily tasks?
  • Are you experiencing symptoms of depression or anxiety?
  • Do you feel like you’re losing a sense of control?
  • Have you been waking up in the middle of the night from nightmares?

Questions you should ask your healthcare provider

If you do have PTSD, it’s important to understand its causes and course of action over the short- and long-term. Here are some of the more important questions to ask your healthcare provider during your appointment:

  • What exactly is post-traumatic stress disorder?
  • How long does PTSD last?
  • Do children react differently than adults to PTSD?
  • How do I live with PTSD?
  • What treatments are available?
  • What is the best medication for me to take?
  • What lifestyle changes can I make to help regulate symptoms of PTSD?

If you’re experiencing PTSD symptoms, your healthcare provider might refer you to a clinical psychologist, psychiatrist, psychotherapist, or other mental health professional to determine what treatment or treatment programs are best.

PTSD treatment options

After receiving your PTSD diagnosis, you’ll want to know all of your options when it comes to treating the disorder. The most popular treatment options include talk therapy, cognitive processing therapy, prolonged exposure therapy, eye movement desensitization and reprocessing (EMDR), stress inoculation training, and medications.

Talk therapy, also known as psychotherapy, is centered around the idea that talking about issues that are bothering you can help put them in perspective. Cognitive processing therapy and prolonged exposure therapy are two of the more common techniques used to help people recover from post-traumatic stress disorder. EMDR was originally designed to alleviate the distress associated with traumatic memories and stress inoculation training (SIT) is another form of cognitive therapy that is used to treat PTSD.

There’s no cure for PTSD—it’s treated symptomatically. However, you can treat your symptoms and prevent them from getting out of hand with a combination of the treatments listed above and approved medications prescribed by your healthcare provider.

PTSD medications

Your healthcare provider may prescribe one or more medications in the following drug classes to help manage PTSD symptoms. Talk to your healthcare provider about which prescription medications are safe for you and remember to always use over-the-counter medicines as directed.

Antidepressants

Antidepressants are medications used to treat depression, anxiety, chronic pain, addiction, and other anxiety disorders. Doctors don’t know exactly how they work but they seem to reduce the intensity of one’s feeling so they are not as overwhelming. Some popular brands are Prozac, Lexapro, Zoloft, and Wellbutrin. Antidepressants can improve your mood, enhance sleep, and increase your appetite and concentration. Common side effects include weight gain, dizziness, headaches, and sexual dysfunction.

Antipsychotics

Antipsychotic medication works by altering certain chemicals in the brain, like dopamine and serotonin. Popular antipsychotics are Abilify, Zyprexa, and Risperdal. These medications are effective in reducing delusions, hallucinations, anxiety, and agitation. Some side effects include stiffness, weight gain, constipation, and drowsiness.

Beta blockers

Beta blockers, also known as beta-adrenergic blocking agents, work by blocking the effects of epinephrine (adrenaline) in your body and reducing your blood pressure. They cause your heart to beat more slowly and with less force, lowering your overall blood pressure. Inderal LA, Zebeta, and Tenormin are common brand names. Beta blockers can improve blood flow and reduce your risk of a heart attack, but they’re known to cause dizziness, fatigue, headache, constipation, reduced libido, and erectile dysfunction.

Benzodiazepines

These medications work by increasing the effects of a brain chemical called gamma-aminobutyric acid (GABA) and act as a sedative, slowing down the body’s functions. Xanax, Klonopin, Valium, and Ativan are some of the more popular benzodiazepines. This type of medicine can help people sleep, reduce anxiety, and relax muscles but are highly addictive and should be used sparingly with the utmost caution. These are not intended for long-term use.

Short-term use of benzodiazepines is generally safe and effective. However, long-term use can lead to dependence on the drug and substance abuse. Side effects may include drowsiness, confusion, trembling, vision problems, and feelings of depression and rebound anxiety.

Monoamine oxidase inhibitors (MAOIs)

Similar to antidepressants, MAOIs work by affecting changes in the brain chemistry that are thought to play a role in depression. Specifically, MAOIs inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A and monoamine oxidase B. Popular brand names include Marplan, Nardil, and Emsam.

When taking MAOIs, people may experience improved mood and less frequent panic attacks. Some of the most common side effects include dry mouth, nausea, drowsiness, insomnia, and headaches. Use of this medication comes with a host of dietary and medication restrictions that when combined can be fatal. Patients are advised to wear a medic alert tag if they are on this medication.

Selective serotonin reuptake inhibitors (SSRIs)

SSRIs work by increasing serotonin levels in the brain and blocking the reabsorption of serotonin into neurons. Some popular brand names are Zoloft, Paxil, Prozac, Lexapro, and Celexa. Paxil and Zoloft are approved by the Food and Drug Administration (FDA) for PTSD treatment. SSRIs are known to help those with anxiety, obsessive-compulsive disorder (OCD), and PTSD. Some side effects include nausea, insomnia, dizziness, sexual dysfunction including decreased libido, erectile dysfunction, and delayed or inability to orgasm for both men and women.

Serotonin-norepinephrine reuptake inhibitors (SNRIs)

SNRIs are a class of antidepressants that can treat anxiety disorders, such as PTSD, OCD, and attention deficit hyperactivity disorder. They work by blocking the reabsorption of serotonin and norepinephrine back into the nerve cells that released them—this increases the levels of active neurotransmitters in the brain.

Common brand names include Cymbalta, Fetzima, Ultram, and Strattera. If you take SNRIs to treat PTSD, you may experience improved mood, fewer panic attacks, and fewer feelings of anxiety. Some side effects include excessive sweating, headaches, dry mouth, and hypertension.

What is the best medication for PTSD?

The best medication for PTSD depends on patients’ symptoms, medical conditions, medical history, and medications they may already be taking that could interact with PTSD medication as well as response to treatment. Talk to your healthcare provider about which medication is safe for you.

Brand name Drug class Administration route Standard dosage How it works Most common side effects
Zoloft (sertraline hcl) SSRI/antidepressant Oral 50 mg tablet It increases the levels of serotonin in the brain, helping to regulate and improve one’s mood. Indigestion, shaking, insomnia, decreased sex drive
Prozac (fluoxetine HCl) SSRI/antidepressant Oral 20 mg capsule This medication works by affecting specific chemicals in the brain that may be unbalanced in patients who have OCD, depression, or panic attacks. Insomnia, headache, upset stomach, dry mouth, decreased sex drive
Zyprexa (olanzapine) Antipsychotic Oral 5 mg tablet This drug blocks the receptors in the brain that are affected by dopamine, controlling symptoms of mania. Weight gain, headache, elevated blood glucose and cholesterol
Tenormin (atenolol) Beta blocker Oral 50 mg tablet It works by blocking natural chemicals in your body on the heart and blood vessels. Dizziness, nausea, slow heart rate
Xanax (alprazolam) Benzodiazepine Oral 1 mg tablet Xanax increases the amount of neurotransmitter GABA in the brain to increase calmness. Trouble concentrating, slurred speech, dizziness
Marplan (benlysta) MAOI Oral 10 mg tablet It increases levels of certain chemicals in the brain, treating depression and anxiety. Chest pain, headache, rapid weight gain
Cymbalta (duloxetine HCl) SNRI Oral 60 mg capsule (delayed-release) It works by increasing the levels of serotonin and norepinephrine, which help regulate mood and block pain signals. Nausea, constipation, fatigue

Dosage is determined by your healthcare provider based on your medical condition, response to treatment, age, and weight. Other possible side effects exist. This is not a complete list.

Common side effects of PTSD medicine

Some common side effects of PTSD medication include:

  • Dry mouth
  • Dizziness
  • Nausea
  • Constipation
  • Diarrhea
  • Tiredness
  • Headaches
  • Insomnia
  • Disordered sexual function

Note: This is not a full list of side effects. Talk to a healthcare professional for a complete list of possible adverse events and drug interactions.

Living with PTSD

If you have PTSD, there are a few lifestyle changes you can make to help you cope with the disorder and prevent future episodes from recurring. Here are a few changes you can make to help alleviate symptoms:

  • Spend time with people: Avoiding social situations may seem like a good idea, but it can actually make PTSD symptoms worse. Create a daily routine that you’re comfortable with to help reduce symptoms of anxiety.
  • Get support when needed: Lean on friends and family to help support you. If you don’t have an inner circle you can count on, look for a support group with people who are facing similar challenges. The National Alliance on Mental Illness (NAMI) can help connect you with a support group and local resources in your area.
  • Avoid drugs and alcohol: Though it can be tempting to use these substances to remedy how you feel when dealing with PTSD, substance use can be dangerous and addictive and make recovery harder in the long run.
  • Practice mindfulness: To reduce stress and anxiety levels, find time for prayer or meditation. Start with one to two minutes of quiet mindfulness every day.
  • Exercise: In addition to quieting your mind, it’s also crucial to get your body moving. Just a 10-minute walk per day can improve your mood and reduce feelings of anxiety and depression. Outdoor activities, such as hiking, can also help treat PTSD.
  • Get enough sleep: Not getting the recommended eight hours of sleep per night can actually worsen and exacerbate symptoms.
  • Eat a balanced diet: Of the foods that you should include in your diet, try to prioritize blueberries, chamomile tea, walnuts, and green vegetables. These foods may relieve PTSD symptoms to some extent.
  • Take supplements: Fish oil, inositol, and n-acetylcysteine may help PTSD symptoms. Consult with your healthcare provider before taking any vitamins or supplements.

Frequently asked questions about PTSD

How long does post-traumatic stress disorder last for?

The course of the illness varies from person to person. Some people may recover from symptoms within six months while others may experience symptoms for years. In order for someone to be diagnosed with PTSD, they must have symptoms for at least a month following the triggering event and last more than six months to meet full PTSD diagnostic criteria.

Can you recover from post-traumatic stress disorder?

You can recover from post-traumatic stress disorder, but it won’t happen overnight. Recovery is a gradual, ongoing process that may involve multiple treatments and medications to help manage symptoms. Though there is no cure for PTSD, there are many steps you can take to cope with the residual symptoms you experience.

What is the most common drug prescribed for PTSD?

The most common drugs prescribed for PTSD are SSRIs like sertraline and fluoxetine. In fact, these drugs are the only FDA-approved drugs for PTSD treatment.

Can PTSD be cured without medication?

Though medications can help manage PTSD symptoms, there are other treatments that can make a difference. Some popular treatment options include talk therapy, cognitive processing therapy, prolonged exposure therapy, virtual reality therapy, eye movement desensitization and reprocessing, and stress inoculation training.

What happens if PTSD goes untreated?

If PTSD goes untreated, those who are affected by the disorder could struggle with alcohol and drug use to find relief. Additionally, sufferers of PTSD can experience severe anger management issues, loneliness, and depression.

Medically reviewed by Raymond ZakhariDNP, EdM, NP-BC
Triple Board-Certified Nurse Practitioner

Raymond Zakhari, DNP, EdM, NP-BC, is a triple board certified nurse practitioner with a diverse clinical background ranging from Intensive Care to medical house calls. He began his career at Duke University Medical center in the cardiothoracic ICU and made his way back to the northeast as a traveling ICU and ER nurse. In 2009 he founded Metro Medical Direct, the first concierge, nurse practitioner owned, medical/ psychiatric house calls and tele-health practice in New York City. Dr. Zakhari was also trained in sex therapy at the New York University School of Medicine/Langone Medical Center and is appointed to the staff of New York PresbyterianHospital, department of internal medicine in psychiatry at the Payne Whitney Clinic. He provides consultative services as a Sexual Assault Forensic Examiner. He is a former officer of the New Jersey Air National Guard and has deployed in support of Operation Iraqi Freedom. He has held adjunct faculty appointments at the Hunter Bellevue School of Nursing, New York University, and Liberty University. Dr. Zakhari hosts a podcast called The Psychology of it All. Over the years, Dr. Zakhari has published in peer-reviewed journals and has presented at both regional and national conferences. He currently is a member of the American Academy of Nurse Practitioners (AANP), the Society for Sex Therapists and Researchers (SSTAR), and the International Association of Forensic Nurses.

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