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Influenza Treatments and Medications

Medically reviewed by Marissa WalshPharm.D., BCPS-AQ ID
Licensed Pharmacist
Updated Apr. 22, 2024  •  Published Aug. 20, 2020
Fact Checked

Flu. It’s that yearly ritual of coughing, sniffling, and calling in sick. We all know the drill. Take a bunch of over-the-counter medicines, hunker down in bed, and wait for the bug to run out of steam. For some people, though, it’s not that easy. Influenza can sometimes advance to a serious and even life-threatening condition. It pays, then, to go into every flu season knowing what flu is, what to expect, and what to do.

What is influenza?

Influenza is a common viral infection that attacks over a billion people annually. The flu virus infects the nose, throat, air passages, and lungs. Influenza comes in many different types, called strains, and can infect both animals and humans. The virus is constantly changing, so the immunity developed is usually obsolete for the next round of seasonal flu.

Influenza has four different major strains, but only three infect humans: influenza A, B, C. Healthcare professionals worry about the A and B strains which are responsible for most illnesses caused by flu. Every year, these two flu strains send about half a million people to the hospital (in the U.S.) and between 12,000 to 60,000 people to their graves. Influenza C, on the other hand, is rarely encountered and causes only mild infections.

On occasion, influenza strains that infect animals cross over into people, including avian (bird) flu and swine flu. These strains can be very dangerous and can cause severe illness.

Influenza is highly contagious and can easily spread from person-to-person in water droplets or aerosols expelled by sneezing, coughing, or talking. The virus can also be acquired by touching contaminated surfaces, objects, or bodily secretions and then touching the nose or mouth.

For some, flu infections resolve without treatment after three to seven days from the initial symptoms, but people can be contagious for up to a week later.

Other people, however, are at risk for more severe infections that can cause serious complications. These include seniors, young children, immune-compromised people, pregnant women, and people with asthma, lung disease, heart disease, or chronic medical conditions.

Pneumonia is the most common complication and the overwhelming reason flu patients end up in the hospital. Other serious flu complications include inflammation of the brain (encephalitis), inflammation of the heart (myocarditis), and Reye’s syndrome, a severe inflammatory condition that can strike children with a viral infection. In some patients the infection triggers a very strong inflammatory response, known as sepsis, which can result in death.

How is influenza diagnosed?

During flu season, most flu cases are diagnosed based on the symptoms, which include

  • Cough
  • Fever
  • Chills
  • Sore throat
  • Nasal congestion
  • Swollen, itchy, or watery eyes
  • Body aches
  • Headache
  • Fatigue
Nausea, vomiting, diarrhea, and aversion to light are also common.

Patients with these more severe symptoms should seek emergency medical care:

  • Shortness of breath
  • Trouble breathing
  • Low blood pressure
  • Chest pain
  • Fast heartbeat
  • Confusion
  • Dizziness
  • Blue skin
  • A high fever (in children)
Of course, fever of any kind in a newborn younger than 12 weeks requires immediate medical care.

For patients at a higher risk for complications or those with severe symptoms, healthcare providers can perform a rapid test to confirm the flu diagnosis. Depending on which rapid test is utilized, there may be false negative results. This is especially true of rapid tests which detect antigen, so the results of this test specifically should always be interpreted in the context of other information available to the healthcare professional such as circulating seasonal influenza, time of onset of symptoms, quality of specimen obtained, and time from specimen collection to processing. Antiviral medication should be started ASAP to be effective, and these tests, though not perfect, can be performed on-site and deliver results in 30 minutes. These rapid tests are generally recommended for use in patients in the community.

For patients requiring hospitalization, it is recommended to definitively diagnose influenza with a PCR, or polymerase chain reaction, test. These tests identify scraps of the influenza virus, and are usually specific enough to discriminate between influenza A and B viruses, sometimes even further into the various subtypes of influenza A. The likelihood of a result being a false negative is very low, and PCR tests can usually yield results in a couple of hours.

Chest X-rays or a CT scan may be required if the infection has advanced to pneumonia.

Flu treatment options

For most, flu winds down in a few days without treatment. Antiviral medications may be recommended as they’ve demonstrated the ability to shorten the duration of viral shedding by an infected person, which can help control potential spread and shorten the duration of symptoms. In some cases, however, complications may require hospitalization in addition to antiviral treatment.

Vaccination

Vaccination is the best way to avoid the flu and prevent its spread. For this reason, the Centers for Disease Control and Prevention (CDC) recommend everyone over the age of 6 months receive a flu vaccine before the start of flu season every year. Flu vaccines protect against three or four different strains of flu, but they will not work against other strains that may pop up. For this reason, flu vaccines prevent flu infection in about 40% to 60% of people who receive the vaccine - mostly depending on how well the annual flu vaccine ends up matching circulating flu viruses.

Medications

Most people can tough their way through a flu infection with rest and the occasional over-the-counter medication. For several reasons, including people at risk for complications,prescription medications will be recommended that fight off the virus or prevent infection.

Hospitalization

Patients with complications may require hospitalization for treatment, support, and observation. Pneumonia is the most common complication. When hospitalized, patients are usually given antiviral medications, but may also be given antibiotics to fight off possible secondary bacterial infections and steroids to reduce swelling and damage in the lungs. If needed, patients may be put on oxygen or a ventilator.

Flu medicine

Prevention is the best medicine, so an annual flu shot should be on everyone’s to-do list. However, flu vaccines don’t come with a guarantee. Fortunately, most people will weather the flu with little more than a few days of rest. People at risk of serious complications—or people hospitalized for serious complications—will be given antiviral medications to control the infection.

Vaccines

Each year, public health authorities determine which influenza strains are most likely to cause serious illness or epidemics the following flu season. They then direct vaccine producers to make vaccines for those selected strains. Trivalent vaccines produce immunity against three flu strains (two A and one B) and quadrivalent vaccines up the ante to four strains (two A and two B). Influenza vaccines are widely available at clinics and pharmacies at affordable prices or for free. The body develops immunity about two weeks after the shot.

Symptom relief medications

Several over-the-counter medications can be used to relieve flu symptoms. None of these medications fight off the virus, but they make life more tolerable as the immune system carries on the fight. NSAIDs (nonsteroidal anti-inflammatory drugs) or acetaminophen relieve aches, sore throat, and fever, while other symptoms can be relieved with cough suppressants, decongestants (stuffy nose), expectorants (chest congestion), and antihistamines (runny nose, swollen eyes, postnasal drip). Combination drugs, such as NyQuil or Theraflu, combine two or more classes of drugs to provide multi-symptom relief.

Antiviral medications

For patients who are at risk for complications or who are hospitalized with the flu, doctors use prescription antiviral medications such as Tamiflu (oseltamivir), Relenza (zanamivir), Rapivab (peramivir), or Xofluza (baloxavir marboxil). These medications interfere with the ability of the virus to further infect human cells or, in the case of baloxavir, to replicate.

Antiviral medications, however, are most effective when given within two days of the onset of symptoms. There is extensive guidance that supports 2 of these medications—oseltamivir and zanamivir— beprescribed to high-risk patients to prevent infection preemptively or after a known exposure.

What is the best medication for the flu?

An ounce of prevention is worth a pound of cure, so healthcare professionals all agree that people should be vaccinated before the start of flu season, as able. This will also help prevent spread and exposure to vulnerable patients who cannot receive vaccination, such as infants less than six months of age. Once the infection hits, however, there is no “best” medication for the flu. Rest and drinking fluids usually do the trick. Antiviral medications only help when the infection becomes a serious threat.

Best medications for flu treatment
Drug Name Drug Class Prevention or treatment? Administration Route Standard Dosage Common Side Effects
Tamiflu (oseltamivir) Neuraminidase inhibitor Treatment or prevention Oral Dosage depends on use for treatment or prevention and patient’s age Nausea, vomiting, headache
Relenza (zanamivir) Neuraminidase inhibitor Treatment or prevention Inhaler Two inhalations (10 mg) once daily (prevention) or twice daily (treatment) Sore throat, cough, sinusitis
Rapivab (peramivir) Neuraminidase inhibitor Treatment Injection 600 mg one time (weight-based dosing for children with a max of 600 mg) Diarrhea, constipation, insomnia
Xofluza (baloxavir marboxil) Endonuclease inhibitor Treatment Oral 40-80 mg as a single dose (dependent on weight) Diarrhea, vomiting, abnormal behavior
Theraflu Flu Sore Throat Pain reliever, cough suppressant, decongestant Symptom relief Oral Depends on dosage form (available as tablets, capsules, liquid, and powder/packet one packet every four hours Drowsiness, anxiety, headache
Motrin (ibuprofen) NSAID Symptom relief Oral Two 200 mg tablets every four to six hours Nausea, stomach pain, skin rash
Tylenol (acetaminophen) Pain reliever Symptom relief Oral Two 325 mg tablets every four to six hours Nausea, stomach pain, loss of appetite
Sudafed Sinus Congestion 24 Hour (pseudoephedrine) Decongestant Symptom relief Oral One 240 mg tablet taken with water every 24 hours Nervousness, restlessness, dizziness

Flu treatment vaccinations

Drug Name Drug Class Prevention or treatment? Administration Route Standard Dosage Common Side Effects
Fluad Trivalent and quadrivalent flu vaccine Prevention: aged 65 years and older Injection One 0.5 ml injection Injection site reactions, muscle pain, malaise
Fluzone High-Dose Quadrivalent flu vaccine Prevention: aged 65 years and older Injection One 0.7 ml injection Injection site reactions, muscle pain, malaise
Afluria Quadrivalent, Quadrivalent flu vaccine Prevention: age greater than or equal to 6 months Injection 6 months to 35 months: one 0.25 ml injection Greater than or equal to 4 years of age: one 0.5 ml injection Injection site reactions, muscle pain, malaise
Fluzone Quadrivalent Quadrivalent flu vaccine Prevention: age greater than or equal to 6 months Injection 6 months to 35 months: one 0.25 ml - 0.5 ml injection Greater than or equal to 4 years of age: one 0.5 ml injection Injection site reactions, muscle pain, malaise
Fluarix Quadrivalent, FluLaval Quadrivalent Quadrivalent flu vaccine Prevention: age greater than or equal to 6 months Injection One 0.5 ml injection
Afluria Quadrivalent, jet injector Quadrivalent flu vaccine Prevention: aged 18 to 64 years of age, only High pressure jet of liquid medication penetrates the skin (without a needle) One 0.5 ml injection Injection site reactions, muscle pain, malaise
Flucelvax Quadrivalent Quadrivalent flu vaccine Prevention: aged 4 years and older with severe egg allergy Injection One 0.5 ml injection Injection site reactions
Flublok Quadrivalent Quadrivalent flu vaccine Prevention: aged 18 years and older with severe egg allergy Injection One 0.5 ml injection Injection site reactions, headache, fatigue
Flumist Quadrivalent flu vaccine Prevention: non-pregnant, aged 2 years to 49 years, without specific medical conditions Nasal spray One 0.1 ml spray into each nostril Runny nose, headache, sore throat
Many of the standard dosages above are from the U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH). Dosage is determined by your doctor based on your medical condition, response to treatment, age, and weight. Other possible side effects exist. This is not a complete list.

What are the common side effects of flu medicine?

Nearly 40% of the adult American population receives a flu vaccine each year, and people spend over 9 billion dollars a year on over-the-counter cold and flu medications. It’s a pretty safe bet that both are relatively safe.

Flu vaccines are very safe. Most people, though, will experience some minor side effects. Injection site reactions, such as pain or redness, are the most common. However, many people just feel bad after the shot. Headache, low fever, nausea, muscle aches—these are fairly common. No-one, however, actually catches flu from the vaccine.

Over-the-counter symptom relief products are also very safe, when taken as recommended. Some healthcare providers don’t recommend combination drugs, instead advising taking medications targeted to the symptoms experienced. This helps prevent taking unneeded medications, following appropriate dosing schedules, and avoiding side effects. All over-the-counter medications should be used as directed. More is never better. Also, over-the-counter flu medications should not be given to a child under 12 unless under the advice of a physician.

Antiviral drugs do not usually cause serious side effects. The most common side effects involve digestive system problems such as nausea, vomiting, and diarrhea. Patients who take zanamivir may also experience cough, swollen sinuses, runny nose, or sore throat likely attributed to its inhaled route of administration. The most serious side effects are skin reactions and psychiatric problems, such as delusions, especially in children and older patients. These, however, are very rare and the benefit of treatment for the flu outweighs the very low risk of these side effects.

What is the best home remedy for the flu?

Because most flu cases are treated at home, there are more flu home remedies than can be counted. None of them actually affects the virus, but many home remedies effectively relieve symptoms. Dietary supplements and alternative medicines can’t hurt, but claims made for zinc, vitamin C, echinacea, black tea, and apple cider vinegar have not been demonstrated to shorten flu infections. Instead, keep to the basics, and the body will do the rest.

Get rest

The body expends a great deal of energy and resources fighting off the flu virus, so now’s the time to catch up on naps and TV shows you haven’t seen in a while.

Drink fluids

Because of fever, diarrhea, and vomiting, dehydration is an ever-present risk with flu and will make the symptoms worse. Drink enough water, juice, and electrolytes throughout the day to keep symptoms at bay.

Humidify

Water vapor can help relieve some flu symptoms and also helps prevent the spread of the virus. If sore throat, cough, or nasal congestion is a problem, consider a steam-filled shower or vaporizer to help manage these symptoms.

Use over-the-counter medications to relieve symptoms

Over-the-counter medications do help relieve symptoms, sometimes dramatically. Healthcare professionals often advise that you only buy medications to relieve symptoms you’re experiencing. Combination drugs are convenient, but they often include medications you don’t need.

Frequently asked questions about influenza

Is influenza A or B worse?

Both influenza A and B can cause serious flu infections, but influenza A historically has caused the most severe flu pandemics and includes some of the most virulent strains, such as H1N1.

How long is the flu contagious?

People infected with flu can spread the virus by coughing, sneezing, talking, singing, or contaminating surfaces or objects from about one day before symptoms begin to five to seven days after symptoms fade.

How long is the flu contagious with Tamiflu?

Tamiflu does not cure the flu or make it less contagious. Instead, it helps to prevent infection or reduce its severity in patients at risk of flu complications. As with any case of flu, patients on Tamiflu are contagious when infected by the virus. They can spread the virus up to a week after symptoms resolve.

Can you get over the flu without going to the doctor?

Most cases of flu resolve in a few days without treatment.

What is the best medicine for the flu?

Health care professionals mostly agree that the best medicine for the flu is to be vaccinated several weeks before flu season. Vaccinations do not work against all strains of the virus, so there is still a possibility that a vaccinated person will fall ill. When they do, most cases of flu will resolve without treatment or medicines. However, patients at risk of severe complications will be given antiviral medications to control the infection.

Is Tamiflu over the counter?

Tamiflu is available only with a doctor’s prescription.

How do you cure the flu quickly?

In most cases, the body must be given a few days to fight off a flu infection. This process can be helped along with plenty of rest and fluids.

Related resources for influenza

Medically reviewed by Marissa WalshPharm.D., BCPS-AQ ID
Licensed Pharmacist

Marissa Walsh, Pharm.D., BCPS-AQ ID, graduated with her Doctor of Pharmacy degree from the University of Rhode Island in 2009, then went on to complete a PGY1 Pharmacy Practice Residency at Charleston Area Medical Center in Charleston, West Virginia, and a PGY2 Infectious Diseases Pharmacy Residency at Maine Medical Center in Portland, Maine. Dr. Walsh has worked as a clinical pharmacy specialist in Infectious Diseases in Portland, Maine, and Miami, Florida, prior to setting into her current role in Buffalo, New York, where she continues to work as an Infectious Diseases Pharmacist in a hematology/oncology population.

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