What is Pamidronate Disodium: Uses, Warnings & Interactions

Updated Jan 13, 2021  •  Published Dec 30, 2020

Pamidronate Disodium overview

BRAND NAMES:

  • Pamidronate Disodium Novaplus

Generic Names:

  • Pamidronate Disodium

Uses:

  • Treats high blood calcium levels (hypercalcemia) in patients with cancer. Also treats bone damage caused by Paget's disease, multiple myeloma, or breast cancer that has spread to the bones. This medicine is a bisphosphonate.

Therapeutic Classes:

  • Calcium Regulator

Forms:

  • Injectable

How it’s taken:

  • By injection

What form(s) does Pamidronate Disodium come in

  • Injectable

What are common Pamidronate Disodium doses?

  • Vial 10ML of 30MG/10ML

  • Vial 10ML of 90MG/10ML

Common Pamidronate Disodium prescriptions

  • Pamidronate Disodium
    30mg solution reconstituted

  • Pamidronate Disodium
    90mg solution reconstituted

  • Pamidronate Disodium
    10ml of 30mg/10ml vial

  • Pamidronate Disodium
    10ml of 6mg/ml vial

  • Pamidronate Disodium
    10ml of 90mg/10ml vial

How to take Pamidronate Disodium

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. However, it is very important to not drink too much liquid. Talk to your doctor about the right amount of liquids for you.

  • Your doctor may also give you vitamins containing Vitamin D and calcium. Tell your doctor if you are unable to take these supplements.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Your doctor may also give you vitamins containing Vitamin D and calcium. Tell your doctor if you are unable to take these supplements.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. However, it is very important to not drink too much liquid. Talk to your doctor about the right amount of liquids for you.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Pamidronate Disodium

  • Injection routeCall your doctor or pharmacist for instructions.

Pamidronate Disodium contraindications

  • You should not receive this medicine if you have had an allergic reaction to pamidronate or to similar medicines such as alendronate, etidronate, risedronate, tiludronate, Actonel®, Didronel®, Fosamax®, or Skelid®. You should not receive this medicine if you are pregnant.

Pamidronate Disodium warnings

  • Swelling in your hands, ankles, or feet

  • Seizures

  • Severe bone, joint, or muscle pain

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • You may need a dental exam before you start to use this medicine. Tell your doctor if you develop pain, swelling, or numbness in your teeth or jaw.

  • Unusual bleeding, bruising, or weakness

  • Trouble breathing

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. Try to avoid major dental work, such as dental surgery, while you are being treated with this medicine.

  • Tell your doctor if you develop severe bone, joint, or muscle pain.

  • This medicine may increase your risk for fractures of the thigh bone. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips.

  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, heart disease, parathyroid problems, or a history of thyroid surgery. Tell your doctor if you have anemia, cancer, dehydration, a mineral imbalance, or a history of problems with your mouth or teeth (such as gum disease or dentures). Make sure your doctor knows if you have been treated with a bisphosphonate medicine in the past.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

Pamidronate Disodium interactions

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may increase your risk for fractures of the thigh bone. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips.

  • Tell your doctor if you develop severe bone, joint, or muscle pain.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. Try to avoid major dental work, such as dental surgery, while you are being treated with this medicine.

  • You may need a dental exam before you start to use this medicine. Tell your doctor if you develop pain, swelling, or numbness in your teeth or jaw.

  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, heart disease, parathyroid problems, or a history of thyroid surgery. Tell your doctor if you have anemia, cancer, dehydration, a mineral imbalance, or a history of problems with your mouth or teeth (such as gum disease or dentures). Make sure your doctor knows if you have been treated with a bisphosphonate medicine in the past.

  • Make sure your doctor knows if you are receiving cancer medicines or radiation treatments. Tell your doctor if you are using thalidomide (Thalomid®), medicine to treat an infection (such as amikacin, gentamicin, streptomycin, tobramycin, Garamycin®, TOBI®), or a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone). Tell your doctor if you also use a pain or arthritis medicine or NSAID such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®.

Pamidronate Disodium side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness

  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting

  • Fast, slow, pounding, or uneven heartbeat

  • Severe bone, joint, or muscle pain

  • Swelling in your hands, ankles, or feet

  • Pain or other problems with your teeth or jaw

  • Decrease in how much or how often you urinate, burning or painful urination

  • Confusion, mental changes, unusual tiredness or weakness, muscle spasms or stiffness

  • Blood in the urine, lower back pain, side pain, or sharp back pain just below the ribs

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Seizures

  • Trouble breathing

Less Serious Side Effects

  • Pain, redness, swelling, or a lump under your skin where the needle is placed

  • Fever, chills, cough, runny or stuffy nose, sore throat

  • Mild nausea, vomiting, constipation, loss of appetite, stomach pain or upset