What is Ledipasvir-Sofosbuvir: Uses, Warnings & Interactions

Updated Jan 25, 2023  •  Published Jan 25, 2023

Ledipasvir-Sofosbuvir overview

BRAND NAMES:

  • Harvoni

Generic Names:

  • Ledipasvir-Sofosbuvir

Uses:

  • Treats chronic hepatitis C. Used together with or without ribavirin.

Therapeutic Classes:

  • Antiviral

Forms:

  • Tablet, Pellet

How it’s taken:

  • By mouth

What form(s) does Ledipasvir-Sofosbuvir come in

  • Tablet

  • Pellet

What are common Ledipasvir-Sofosbuvir doses?

  • Box 28 tablets

Common Ledipasvir-Sofosbuvir prescriptions

  • Ledipasvir-Sofosbuvir
    28 tablets box

How to take Ledipasvir-Sofosbuvir

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the medicine in its original container.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral pellets: Do not open the packet until ready to use. Do not use a packet if the seal is broken or damaged.Hold the packet with the cut line on top and shake it gently to settle the pellets.Tear or cut the packet along the cut line.Swallow the oral pellets with water. Do not crush or chew them. If the oral pellets are taken with food, sprinkle the pellets on 1 or more spoonfuls of non-acidic soft food (such as pudding, chocolate syrup, mashed potato, and ice cream) at or below room temperature. Swallow the mixture right away (within 30 minutes). Do not save any of the mixture to use later.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

Ledipasvir-Sofosbuvir contraindications

  • This medicine is not right for everyone. Do not use it together with ribavirin if you are pregnant or your sexual partner is pregnant.

Ledipasvir-Sofosbuvir warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, other liver disease (including hepatitis B), or heart disease. Tell your doctor if you had a liver transplant.

  • Ribavirin may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Follow all directions about birth control.

Ledipasvir-Sofosbuvir interactions

  • Amiodarone can cause serious side effects if used together with this medicine.

  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:Atorvastatin, digoxin, rifabutin, rifampin, rifapentine, rosuvastatin, simeprevir, tenofovir, tipranavir/ritonavir, St John's wortBlood pressure medicineCancer medicineMedicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)Steroid medicineStomach medicine (including famotidine, omeprazole)

  • If you take an antacid that contains aluminum or magnesium, take it 4 hours before or after you take this medicine.

Ledipasvir-Sofosbuvir side effects

Serious Side Effects

  • Lightheadedness or fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, slow heartbeat

Less Serious Side Effects

  • Tiredness, weakness

  • Headache, trouble sleeping

  • Diarrhea, nausea